Immunohistochemical distribution of laminin in squamous cell carcinoma of the head and neck--correlations between laminin staining and clinical and histological features

Nihon Jibiinkoka Gakkai kaiho
M Suzuki

Abstract

The distribution of the basement membrane glycoprotein laminin was investigated immunohistochemically in 66 patients with squamous cell carcinoma of the head and neck region. There were 18 patients with laryngeal cancer, 23 with pharyngeal cancer, 11 with maxillary cancer, and 14 with oral cancer. The specimens were taken from untreated primary lesions, and laminin was detected using the avidin-biotin-peroxidase complex method. In carcinoma tissue, staining was seen in border zone between the cancer cells and surrounding connective tissue, but discontinuity or disappearance of the staining was commonly observed. The patients were classified on the basis of laminin distribution into the following three groups: a normal group, in which staining was almost continuous around the cancer cells, a discontinuous group, in which staining was discontinuous but present in up to 50% of the cancer cells, and an absent group, in which staining was seen in 49% or less of cancer cells. These groups were matched against clinical and histological features. Laminin distribution was significantly correlated with metastasis, survival rate and keratinization. In the absent group, 12 (92%) of the 13 patients had lymph node metastasis, and 6 (46%) had...Continue Reading

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