PMID: 9165447May 1, 1997Paper

Immunohistochemical distribution of surfactant apoprotein-A in congenital diaphragmatic hernia

Journal of Pediatric Surgery
Koushi AsabeM Kajiwara

Abstract

The high mortality for congenital diaphragmatic hernia (CDH) has been attributed to a combination of pulmonary hypoplasia and persistent pulmonary hypertension. Recent experimental studies suggest that surfactant deficiency may also contribute to CDH pathophysiology. In this report, the authors immunohistochemically and morphometrically examined whether or not the hypoplastic lungs of CDH are associated with the immaturity of the surfactant system, especially alveolar type II cell function. Nine autopsy cases with CDH were immunohistochemically examined for the expression of surfactant apoprotein, using anti-IgG against human surfactant apoprotein A (SP-A), and the findings were compared with those in a gestational and postnatal age-matched control group. The lung/body weight ratio in the CDH was less than that in the controls (0.010 +/- 0.005 versus 0.021 +/- 0.013, P < .01). The radial alveolar count (RAC) of the CDH cases were also significantly less than that of the control cases (2.10 +/- 0.52 versus 3.48 +/- 0.39, P < .01). In the CDH cases, the RAC of the lung on the affected side were also significantly less than that of the lung on the unaffected side (1.71 +/- 0.34 versus 2.50 +/- 0.26, P < .01). In the immunohistoche...Continue Reading

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Citations

Apr 24, 2001·Pharmacology & Therapeutics·B WeinbergerJ D Laskin
Mar 19, 2005·Critical Care : the Official Journal of the Critical Care Forum·Sally H Vitali, John H Arnold
Aug 7, 2007·PLoS Medicine·Olivier BoucheratJacques R Bourbon
Aug 7, 2007·PLoS Medicine·Marcus Davey
Jun 16, 2006·Paediatric Drugs·Enrique M OstreaHerbert G Uy
Nov 18, 2004·Journal of Pediatric Surgery·Christopher E ColbyUNKNOWN Congenital Diaphragmatic Hernia Study Group
Jun 9, 2004·Journal of Pediatric Surgery·Kevin P LallyUNKNOWN Congenital Diaphragmatic Hernia Study Group
Jan 12, 2001·Seminars in Perinatology·C S Muratore, J M Wilson
Jul 30, 2005·Seminars in Perinatology·Robbert Rottier, Dick Tibboel
Nov 9, 2011·The American Journal of Pathology·Rhiannon B van LoenhoutRichard Keijzer
Oct 8, 1999·Pediatrics in Review·K Van Meurs, B Lou Short
Nov 16, 2007·The Journal of Obstetrics and Gynaecology Research·Koushi AsabeTakayuki Shirakusa
Sep 30, 2017·Frontiers in Pediatrics·Francesco MoriniPietro Bagolan
Mar 18, 2003·The Journal of Pediatrics·Daphne J M T JanssenLuc J I Zimmermann

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