Immunohistochemical distribution of tubulin beta II in human normal and neoplastic tissues

The Kurume Medical Journal
Eriko OdaMasamichi Kojiro

Abstract

Tubulin is the major constituent protein of microtubules. In mammals, there are seven beta-tubulins and six alpha-tubulins. Each beta-tubulin isotype has a unique tissue distribution. The purpose of this study was to describe the distribution of tubulin beta II in normal and neoplastic human tissues with immunohistochemical techniques. We obtained normal tissues from 33 cases (8 fetuses, 17 neonates, 3 children and 5 adults) and 121 samples of neoplastic tissue from surgical specimens or at autopsy. Immunohistochemical staining for tubulin beta II was performed using a monoclonal antibody, KNY379 developed in our laboratory. Tubulin beta II was detected in various normal tissues, particularly in fetal and neonatal tissues, such as the nervous system, pulmonary alveoli, bronchioles and bronchi, colon, pancreatic ducts and acini, renal convoluted tubuli, skin epidermis, body cavity mesothelial cells, smooth muscle and thymus. In the adult, broad expression was also observed; however, the immunoreactivity was weaker and the extent of its distribution decreased with age. In neoplastic tissues, tubulin beta II immunoreactivity was detected in various nervous system neoplasms and other neoplasms such as pancreatic solid cystic carcin...Continue Reading

References

Sep 1, 1992·Journal of Neuroscience Research·M D RobersonP Morell
Mar 1, 1992·The American Journal of Surgical Pathology·K ChangM C Willingham
May 1, 1985·The American Journal of Surgical Pathology·A Churg
Jan 1, 1988·Annual Review of Cell Biology·K F Sullivan
Sep 1, 1985·The Journal of Cell Biology·S A LewisN J Cowan
Jan 14, 1994·Brain Research. Developmental Brain Research·M M Oblinger, S A Kost
Nov 20, 1995·The Journal of Comparative Neurology·C M PadenM M Oblinger
Sep 1, 1996·The American Journal of Surgical Pathology·C DoglioniG Viale
Sep 9, 2000·Hearing Research·R Hallworth, R F Ludueña
Dec 18, 2001·Cell Motility and the Cytoskeleton·C Walss-BassR F Ludueña
May 31, 2002·Cell and Tissue Research·Consuelo Walss-BassRichard F Ludueña
Jul 12, 2002·Cell Motility and the Cytoskeleton·Katsuhiko AraiHiroshi Matsuda
Sep 5, 2002·Cell Motility and the Cytoskeleton·Keliang Xu, Richard F Ludueña
Apr 16, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Yasuhiro NakamuraHideyuki Okano
May 13, 2003·Cell Motility and the Cytoskeleton·Christos D KatsetosSverre J Mörk
Aug 21, 2003·Breast Cancer Research : BCR·James H DozierSharon Lobert
Oct 7, 2004·Cancer Biology & Therapy·Jan M WoynarowskiJohn R Macdonald

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
B A Eipper
Nature Reviews. Molecular Cell Biology
Stefan Westermann, Klaus Weber
© 2022 Meta ULC. All rights reserved