Immunohistochemical evaluation after Sr-enriched biphasic ceramic implantation in rabbits femoral neck: comparison of seven different bone conditions

Journal of Materials Science. Materials in Medicine
Janis ZarinsJanis Locs

Abstract

Strontium (Sr) has shown effectiveness for stimulating bone remodeling. Nevertheless, the exact therapeutic values are not established yet. Authors hypothesized that local application of Sr-enriched ceramics would enhance bone remodeling in constant osteoporosis of rabbits' femoral neck bone. Seven different bone conditions were analyzed: ten healthy rabbits composed a control group, while other twenty underwent ovariectomy and were divided into three groups. Bone defect was filled with hydroxyapatite 30% (HAP) and tricalcium phosphate 70% (TCP) granules in 7 rabbits, 5% of Sr-enriched HAP/TCP granules in 7, but sham defect was left unfilled in 6 rabbits. Bone samples were obtained from operated and non-operated legs 12 weeks after surgery and analyzed by histomorphometry and immunohistochemistry (IMH). Mean trabecular bone area in control group was 0.393 mm2, in HAP/TCP - 0.226 mm2, in HAP/TCP/Sr - 0.234 mm2 and after sham surgery - 0.242 mm2. IMH revealed that HAP/TCP/Sr induced most noticeable increase of nuclear factor kappa beta 105 (NFkB 105), osteoprotegerin (OPG), osteocalcin (OC), bone morphogenetic protein 2/4 (BMP 2/4), collagen type 1α (COL-1α), interleukin 1 (IL-1) with comparison to intact leg; NFkB 105 and OPG ra...Continue Reading

References

Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Dec 3, 2005·The Journal of Clinical Investigation·Lawrence G Raisz
Jan 24, 2009·Immunological Reviews·David M Mosser, Xia Zhang
Dec 31, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Jeffrey LangeRalph S Marcucio
Aug 4, 2010·International Immunology·Young-Mi LeeYoichiro Iwakura
Dec 2, 2010·Cell and Tissue Research·Anna NeveFrancesco Paolo Cantatore
Oct 4, 2011·Calcified Tissue International·Hankui ChenNalini Chandar
Nov 22, 2011·The Journal of Biological Chemistry·Won-Gu JangJeong-Tae Koh
Nov 29, 2011·Immunology·Ingrid U SchraufstatterRichard G Discipio
May 3, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Simon Y TangTamara Alliston
Sep 4, 2012·Journal of Biomedical Materials Research. Part a·Beena G MohanAnnie John
May 28, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Andreia FigueiredoMargarida Figueiredo
Jun 14, 2013·Journal of Orthopaedic Surgery and Research·Martin BaierChristian Kasperk
Nov 20, 2013·Journal of Pharmacology & Pharmacotherapeutics·Jaykaran Charan, N D Kantharia
May 27, 2014·Materials Science & Engineering. C, Materials for Biological Applications·Satish S SinghPrashant N Kumta
Jun 5, 2014·Current Osteoporosis Reports·Tamara Alliston
Dec 11, 2014·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Simonas GrybauskasLiga Berzina-Cimdina
Nov 4, 2015·Clujul medical : revistă de medicină şi farmacie·Gheorghe Tomoaia, Roxana-Diana Pasca
Jan 20, 2016·Genetics and Molecular Research : GMR·B LiX D Zhang
Mar 1, 2016·European Journal of Pharmacology·Soledad Herrero, Yolanda Pico
Mar 31, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Agata Jabłońska-TrypućStanisław Rosochacki
Dec 9, 2016·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Elena CalciolariNikos Mardas
Feb 16, 2017·Journal of Materials Science. Materials in Medicine·L RobinsonA R Boyd
Mar 10, 2018·Materials Science & Engineering. C, Materials for Biological Applications·Mandy QuadeMichael Gelinsky
May 11, 2018·Bioactive Materials·Wenhao Wang, Kelvin W K Yeung

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