Immunohistochemical evaluation of fibrovascular and cellular pre-iridal membranes in dogs

Veterinary Ophthalmology
Bianca S BauerBruce H Grahn


Histologically, two morphologically distinct types of pre-iridal membranes appear to occur in diseased canine globes: fibrovascular and cellular. Cellular pre-iridal membranes of corneal endothelial origin exist in iridocorneal endothelial (ICE) syndrome in humans and arise through metaplastic transformation of corneal endothelial cells into epithelial-like cells.(1) The purpose of this study was to (i) evaluate immunohistochemical staining of these two types of membranes in diseased canine globes, (ii) determine whether endothelial cell metaplasia or iridal vascular budding plays a role in cellular membrane formation and (iii) compare the primary histopathologic diagnosis between the two groups. Hematoxylin and eosin (H&E)-stained slides of 28 enucleated canine specimens with pre-iridal membranes were randomly selected and examined with light microscopy. The globes were divided into two groups based on the appearance of the membrane: fibrovascular or cellular, and the histopathologic diagnoses were recorded. Immunohistochemical staining for vimentin, cytokeratin AE1/AE3, and Von Willebrand's factor (Factor VIII) was completed on the slides of each globe. The histopathologic diagnoses were compared between the two groups. The f...Continue Reading


Mar 1, 1978·Survey of Ophthalmology·S Gartner, P Henkind
Jan 1, 1992·Acta histochemica·M KasperB Lane
Jan 1, 1987·Histopathology·M LeaderK Henry
Mar 1, 1967·American Journal of Ophthalmology·R R Schulze
Jan 1, 1996·Cornea·S G LevyA C McCartney
Apr 21, 2007·Veterinary Ophthalmology·Carrie B BreauxBruce H Grahn
Jul 5, 2008·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·José A Ramos-VaraUNKNOWN American Association of Veterinary Laboratory Diagnosticians Subcommittee on Standardization of Immunohistochemistry
Feb 13, 2010·Veterinary Ophthalmology·Mitzi K ZarfossRichard R Dubielzig
Dec 14, 2011·Veterinary Pathology·P LabelleA L Labelle

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Oct 13, 2015·The Veterinary Clinics of North America. Small Animal Practice·Gillian BeamerStefano Pizzirani
Jul 19, 2013·Veterinary Ophthalmology·Elizabeth M CurtoDavid A Wilkie

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