PMID: 16518065Mar 7, 2006Paper

Immunohistochemical evaluation of hormone receptor status for predicting response to endocrine therapy in metastatic breast cancer

Breast Cancer : the Journal of the Japanese Breast Cancer Society
Hiroko YamashitaHirotaka Iwase

Abstract

The importance of establishing hormone receptor status of tumors for the treatment of women with hormone receptor-positive breast cancer has been emphasized, however, there is no general agreement as to how immunohistochemical assays should be evaluated. It is critical to evaluate hormone receptor status when considering response to endocrine therapy. Estrogen receptor (ER) and progesterone receptor (PgR) expression was examined by immunohistochemistry using Allred's score for primary breast tumors from 75 metastatic breast cancer patients who received first-line treatment with endocrine therapy (56 patients received tamoxifen, 11 patients received aromatase inhibitors, and 8 patients received LH-RH agonist or other endocrine reagents) on relapse. Correlation between hormone receptor status and response to endocrine therapy as well as post-relapse survival was analyzed. The most significant correlation between positive ER expression and response to any endocrine therapy (p = 0.011) or tamoxifen only (p = 0.030) occurred when the cutoff score was set at 10%. When the evaluation was based on Allred's score (TS), a cutoff point of TS>or=4 showed a more significant association between positive ER expression and response to all kind...Continue Reading

References

Jun 28, 1997·BMJ : British Medical Journal·R M Elledge, C K Osborne
Jan 20, 1999·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D M BarnesR E Leake
May 20, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J M HarveyD C Allred
Mar 6, 2003·Journal of the National Cancer Institute·C Kent OsborneRachel Schiff
May 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Valerie-Jeanne BardouGary M Clark
Jul 9, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Aron GoldhirschHans-Jörg Senn
Sep 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Grazia ArpinoRichard M Elledge

❮ Previous
Next ❯

Citations

Oct 24, 2008·International Journal of Clinical Oncology·Hiroko Yamashita
Jul 15, 2011·Breast Cancer Research and Treatment·Nobuyasu YoshimotoHiroko Yamashita
Jun 20, 2012·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shunzo KobayashiTatsuya Toyama
Feb 4, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·James A KrausRohit Bhargava
Apr 6, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lisa BraunSebastian Aulmann
Dec 2, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H YamashitaS Kobayashi
Feb 3, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H AndersonM Dowsett
Aug 1, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·O BrouckaertP Neven
Apr 17, 2012·Applied Immunohistochemistry & Molecular Morphology : AIMM·Sharon Nofech-MozesWedad M Hanna
Mar 26, 2013·Journal of Clinical Pathology·Ming LeePuay Hoon Tan
Apr 19, 2012·BMC Cancer·Masaaki KawaiYoichiro Kakugawa
Apr 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M Elizabeth H HammondAntonio C Wolff
Sep 23, 2014·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shinobu Masuda
Sep 26, 2007·Expert Review of Anticancer Therapy·Giuseppe CuriglianoAron Goldhirsch
Apr 28, 2016·Molecular Therapy Oncolytics·Koichiro ShojiChieko Kai
May 23, 2012·Clinical Oncology : a Journal of the Royal College of Radiologists·S Nofech-MozesW M Hanna
May 22, 2007·Hematology/oncology Clinics of North America·Hope S Rugo
Jun 8, 2011·Reproduction in Domestic Animals = Zuchthygiene·N SleeckxL Van Brantegem
Jan 10, 2012·Cytopathology : Official Journal of the British Society for Clinical Cytology·S P Bueno AngelaC T Soares
Nov 15, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Anne KatchyCecilia Williams
May 7, 2016·Gynécologie, obstétrique & fertilité·Y ZemmouriC Bonneau
Feb 26, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Rie HoriiHirofumi Mukai
Jun 5, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·F AsghariT Kazemi
Jul 16, 2014·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Rie HoriiHirofumi Mukai
May 18, 2016·International Journal of Molecular Sciences·Florenza Lüder RipoliIngo Nolte
Aug 10, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Roman Mezencev, Marián Švajdler
Jun 15, 2016·Clinical Breast Cancer·Bao C NguyenCurtis J Wray
Sep 2, 2014·The Breast : Official Journal of the European Society of Mastology·Naoko HonmaFutoshi Akiyama
Jul 18, 2015·FEBS Letters·Tomohiko FukudaTomoyuki Fujii
Sep 16, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Akiko OgiyaUNKNOWN Collaborative Study Group of Scientific Research of the Japanese Breast Cancer Society
May 25, 2016·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hope S RugoHarold J Burstein
Sep 19, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emad A RakhaIan O Ellis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.