PMID: 6165077Jan 1, 1981Paper

Immunohistochemical evaluation of J-chain expression by intra- and extra-follicular immunoglobulin-producing human tonsillar cells

Scandinavian Journal of Immunology
F R Korsrud, P Brandtzaeg

Abstract

Cytoplasmic J-chain expression by Ig-producing cells was characterized immunohistochemically in normal specimens of palatine and nasopharyngeal tonsils (adenoids). Altogether follicular immunocytes, which were mainly of ther IgG and IgM isotypes, showed a much higher percentage of J-chain positivity than the extrafollicular ones, in agreement with the idea that this polypeptide is principally a marker of differentiating or newly differentiated Ig-producing cells. Thus, in concurrence with the predominating IgG isotype, J-chain expression was almost 50% in the germinal centres of lymphoid follicles but only about 2% in the extrafollicular compartment. By contrast, a substantial number of J-chain-positive IgA immunocytes were found in the latter compartment. Since it is believed that extrafollicular Ig-producing cells are mainly derived from follicular centre cells, this result indicated that significant isotype switching is involved in tonsillar B-cell differentiation. Most tonsillar IgD immunocytes were J-chain-positive, in accordance with the notion that IgD expression is a feature of relatively early clonal development. It is postulated that J-chain-positive B-cell blasts may leave the tonsils and, through isotype switching, ...Continue Reading

References

Jul 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·W C RaschkeM E Koshland
Aug 1, 1979·Journal of Clinical Pathology·P Isaacson
Apr 1, 1978·The Journal of Experimental Medicine·S J BlackL A Herzenberg
Sep 1, 1975·Scandinavian Journal of Immunology·P Brandtzaeg
Jan 1, 1975·Scandinavian Journal of Immunology·P Brandtzaeg, P Berdal
Dec 26, 1970·Nature·M S Halpern, M E Koshland

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Citations

Jan 1, 1985·Virchows Archiv. A, Pathological Anatomy and Histopathology·G Kelényi
Dec 10, 2003·International Journal of Pediatric Otorhinolaryngology·P Brandtzaeg
Apr 3, 2001·Molecular Immunology·J L Preud'hommeE Lelièvre
Sep 6, 2001·The Journal of Experimental Medicine·L ErlandssonT Leanderson
Dec 3, 1999·Immunological Reviews·P BrandtzaegT Yamanaka
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·Per Brandtzaeg
Jan 1, 1985·Scandinavian Journal of Gastroenterology. Supplement·P Brandtzaeg
Nov 15, 2011·Cellular Immunology·Evdokiya S ReshetnikovaAlexander V Taranin
Jun 3, 2005·Anatomia, histologia, embryologia·P Kumar, J F Timoney
Aug 24, 2010·Immunological Reviews·Kang Chen, Andrea Cerutti
Jul 1, 1991·Clinics in Dermatology·C C Otley, R P Hall
Feb 1, 1991·Journal of Autoimmunity·R P Hall
Jun 30, 1983·Annals of the New York Academy of Sciences·P Brandtzaeg
Nov 1, 1983·The Journal of Pathology·E L Jones
Sep 1, 1983·International Journal of Pediatric Otorhinolaryngology·G Siegel
Feb 24, 2001·The Annals of Otology, Rhinology, and Laryngology·J L GorfienL Brodsky
Nov 1, 1988·Journal of Oral Pathology·I MoroN Okamura
Oct 1, 1981·Scandinavian Journal of Immunology·R Paganelli, R J Levinsky
Jul 29, 2005·Immunological Reviews·Per Brandtzaeg, Finn-Eirik Johansen
Jan 1, 1986·Annals of the New York Academy of Sciences·F ClavelJ Chrétien
Sep 23, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Caitlin D Castro, Martin F Flajnik
Mar 1, 1995·Infection and Immunity·M Quiding-JärbrinkC Czerkinsky
Jun 1, 1987·Journal of the American Academy of Dermatology·R P Hall

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