Immunohistochemical evaluation of mast cells and angiogenesis in oral squamous cell carcinoma

Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
Bhushan SharmaB Sivapathasundharam

Abstract

Angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and immune cells. It has been reported to be associated with progression, aggressiveness and metastases of various malignant tumors including oral squamous cell carcinoma (OSCC). Similarly, mast cells have also been reported to play a role in tumor progression and metastases by promoting angiogenesis. The present study aims at comparison of microvascular density (MVD) and mast cell density (MCD) in normal oral mucosa (NM) and among various grades of OSCC. MVD was assessed immunohistochemically using anti-Factor VIII related von Willebrand factor, and MCD using anti-mast cell tryptase in a study sample of 30 cases of OSCC and 10 cases of clinically normal oral mucosa. The mast cells in normal oral mucosa and oral squamous cell carcinoma strongly expressed mast cell tryptase. The density of mast cells and micro vessels were significantly higher in OSCC compared to normal oral mucosa. The MCD and MVD were higher in moderately differentiated OSCC than in well differentiated OSCC ( P > 0.05) and normal oral mucosa ( P < 0.05). Pearson's correlation revealed a positive correlation between MCD and MVD ( r=0.33; P=0.077). These findings indicate t...Continue Reading

References

Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Nov 1, 1994·American Journal of Surgery·J K WilliamsM J Jurkiewicz
Jun 19, 1993·International Journal of Cancer. Journal International Du Cancer·D M ParkinJ Ferlay
Jun 1, 1997·The Journal of Clinical Investigation·R J BlairB L Gruber
Jul 13, 2000·The Annals of Thoracic Surgery·M TomitaT Onitsuka
Sep 8, 2001·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·J CarlileA M Schor
Sep 13, 2001·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·M TomitaT Onitsuka
Oct 16, 2004·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Yi-Shing ShiehLong-Chang Chang
Aug 30, 2005·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Toshihiko IbarakiMizuo Miyazaki
Sep 19, 2006·Oral Oncology·Helenisa Helena Oliveira-NetoAline Carvalho Batista
Jan 1, 2008·The Open Dentistry Journal·E Z MichailidouD Z Antoniades

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Citations

Feb 2, 2013·Journal of Clinical and Diagnostic Research : JCDR·Vineet Singh CheemaP D Balamurali
Oct 11, 2016·Journal of Oral and Maxillofacial Pathology : JOMFP·Pramod Sangamesh IngaleshwarK M Mithun
Aug 24, 2013·Brazilian Dental Journal·Deise Souza Vilas BôasJean Nunes dos Santos
Dec 15, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Himanshi ChawlaJeyaseelan Augustine
Nov 9, 2017·Applied Immunohistochemistry & Molecular Morphology : AIMM·Rebeca C M DantasClarissa A Gurgel Rocha

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