Abstract
Surgically resected specimens of skin appendage tumors, spiradenoma, poroma of eccrine glands, syringoadenoma, syringoadenoma papilliferum and mixec tumor of skin were evaluated for tenascin, as well as the basement membrane-associated protein laminin, and the extracellular matrix protein fibronectin, using immunohistochemical methods. In normal sweat glands, tenascin was localized as a delicate, thin band in the immediate vicinity of the basement membrane and laminin was limited to the basement membrane. Tenascin in syringoadenoma was also expressed linearly adjacent to the basement membrane. Mixed tumors of skin showed a characteristic distribution of tenascin in the modified myoepithelial cell area adjacent to the tumor epithelia with a heterogeneous pattern, and particularly strong expression in the hyalinous and chondroid areas. In addition, the localization of laminin in the basement membranes of tumors, intracellular immunoreactivity was observed in syringoadenoma, syringocystadenoma papilliferum, and mixed tumor of skin. Fibronectin reactivity was visualized as a diffuse staining in the tumor stroma of eccrine poroma but its expression was restricted in eccrine spiradenoma. The present study suggests a heterogeneity in ...Continue Reading
References
Feb 1, 1990·Archives of Dermatology·M R WickT T Sun
Apr 1, 1991·International Journal of Cancer. Journal International Du Cancer·P G NataliL Zardi
Jul 1, 1991·Human Pathology·G K KoukoulisI Virtanen
Jan 1, 1990·Annals of the New York Academy of Sciences·R TimplR Deutzmann
Feb 1, 1990·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K BeckJ Engel
Oct 10, 1986·Cell·R Chiquet-EhrismannT Sakakura
Dec 1, 1988·The Journal of Cell Biology·E J MackieD Liverani
Oct 1, 1988·Journal of Neuroscience Research·M Bronner-Fraser
Jun 1, 1989·The Journal of Cell Biology·V A LightnerH P Erickson
Jan 1, 1989·Annual Review of Cell Biology·H P Erickson, M A Bourdon
Jun 1, 1985·The Journal of Cell Biology·E G HaymanE Ruoslahti
Apr 1, 1989·European Journal of Biochemistry·R Timpl
Oct 1, 1986·Developmental Biology·M Bronner-Fraser
Jan 1, 1988·Annual Review of Biochemistry·E Ruoslahti
Jan 1, 1987·Annual Review of Cell Biology·G R Martin, R Timpl
Jan 1, 1987·Kardiologiia·Iu B BelousovE P Panchenko
Dec 1, 1986·The Journal of Cell Biology·P SavagnerJ P Thiery
Jan 1, 1994·European Journal of Cancer. Part B, Oral Oncology·P ShresthaM Mori
Dec 4, 2002·Histopathology·T TashiroT Sano