Immunohistochemical evaluation of the microvascular density through the expression of TGF-beta (CD 105/endoglin) and CD 34 receptors and expression of the vascular endothelial growth factor (VEGF) in oligodendrogliomas

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Gabriel Corteze NettoLígia Maria Barbosa Coutinho

Abstract

Angiogenesis has been proposed as essential for the growth of solid tumors. The determinants of this process, the growth factors and the vascular endothelial receptors have brought a potential in the tumor prognostic determination as well as perspectives of "targets" for antiangiogenic therapy. In oligodendrogliomas (OL), angiogenesis is little known and/or has generated conflicting results. In order to clarify angiogenesis in OL, we have evaluated the immunohistochemical expression of vascular endothelial growth factor (VEGF) and the microvascular density (MVD) through the expression of TGF-beta (CD105/endoglin) (MVD-CD105) and CD34 (MVD-CD34) receptors using the Chalkley point method in 30 OL. No significant immune reaction was found for the VEGF. There was expression in <10% of tumor cells and/or staining of weak intensity in 15 (50.0%), >10% of cells and moderate intensity staining in 1 (3.33%), and negative expression in 14 (46.67%). If present, the expression was restricted to tumor and endothelial cells. Our findings suggest that VEGF has little influence on OL angiogenesis. All specimens showed CD105 and CD34 expression in the intratumor vascular endothelium, suggesting involvement of CD105 in OL angiogenesis. The mean ...Continue Reading

References

Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Aug 12, 1971·The New England Journal of Medicine·J Folkman
Sep 1, 1993·Baillière's Clinical Haematology·A Le QuerrecG Tobelem
Nov 1, 1994·Acta Neurologica Scandinavica·M R TolaV Govoni
Dec 1, 1996·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P B VermeulenL Y Dirix
Apr 29, 1998·Neuropathology and Applied Neurobiology·C ChristovR K Gherardi
May 21, 1999·Journal of Immunotherapy·M Herlyn
Jan 8, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C LiS Kumar
May 4, 2000·The New England Journal of Medicine·G C BlobeH F Lodish
Sep 23, 2000·Nature·G D YancopoulosJ Holash
Sep 23, 2000·Nature·P Carmeliet, R K Jain
Feb 22, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R T PoonJ Wong
Oct 6, 2001·Frontiers in Neuroendocrinology·S Hentges, D K Sarkar
Jun 18, 2002·Acta Neurologica Scandinavica·J VaqueroS Coca
Jul 27, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P B VermeulenL Y Dirix
Aug 22, 2002·Journal of Neuro-oncology·Andrey KorshunovRegina Sycheva
Jan 8, 2003·Seminars in Oncology·Judah Folkman
May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sarah E DuffShant Kumar
Apr 14, 2004·Journal of Internal Medicine·Peter Carmeliet
Jun 15, 2004·Journal of Translational Medicine·Ester Fonsatti, Michele Maio
Aug 6, 2004·Endocrine Reviews·Napoleone Ferrara

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Citations

Sep 6, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Hyuk ChangGen Murakami
Aug 16, 2011·Neuropsychology Review·Gerry A Stefanatos, Ida Sue Baron
Oct 14, 2008·Hybridoma·Davoud AhmadvandMohammad Mohammadi
Nov 22, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Nunung Nur RahmahKazuhiro Hongo
Feb 18, 2016·Medicine·Xiangyi KongRenzhi Wang
May 16, 2013·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Zhongzheng JiaJun Zhang
Dec 11, 2008·Brain Pathology·Dana MustafaJohan M Kros
Aug 27, 2014·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Chong Huat SiarKok Han Ng
May 9, 2013·Microvascular Research·Antonio Di IevaMichael D Cusimano
May 8, 2018·Applied Immunohistochemistry & Molecular Morphology : AIMM·Suéllen Trentin BrumAndresa Borges Soares
Dec 22, 2015·International Journal of Cancer. Journal International Du Cancer·Rana HatemElisabetta Marangoni
Sep 16, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Philipp KronPierre-Alain Clavien
Jan 12, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Marcelo Gadelha VasconcelosLélia Maria Guedes de Queiroz
Dec 21, 2011·Journal of Neuro-oncology·Nunung Nur RahmahKazuhiro Hongo
Jun 8, 2014·Journal of Neuro-oncology·Xin ChenQi Pang
Aug 16, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ting-Fang DongTong Li

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