PMID: 93719Sep 1, 1979Paper

Immunohistochemical evidence for an intracellular localization of plasma proteins in human foetal choroid plexus and brain

Neuroscience Letters
K MøllgårdN R Saunders

Abstract

The intracellular distribution of plasma proteins in human foetal choroid plexus and brain was investigated by immunohistochemistry. Small groups of cells or single scattered cells in the epithelial layer of the choroid plexus exhibited positive staining for alpha-fetoprotein, albumin and transferrin, whereas prealbumin was found in the majority of the epithelial cells. Numerous nerve cells in the cerebral wall and in various brain stem nuclei were positively stained for alpha-fetoprotein, albumin and prealbumin. All appropriate controls were negative. The presence of plasma proteins within choroid plexus epithelial cells suggest that these proteins are transported from blood to CSF by a transcellular route across the choroid plexus epithelium. The intracellular distribution of plasma proteins in developing neurons may indicate that these proteins play some important role in neuronal differentiation or development.

References

Jan 1, 1977·Experimental Eye Research·N R Saunders
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Jul 1, 1967·The Journal of Cell Biology·T S Reese, M J Karnovsky
Apr 15, 1981·Developmental Biology·K M DziegielewskaN R Saunders

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Citations

Oct 1, 1988·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·M Matsuda
Aug 16, 1984·Biochemical and Biophysical Research Communications·M J VillacampaJ Uriel
Jan 1, 1982·The International Journal of Biochemistry·A PiñeiroJ Naval
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Aug 15, 1992·Journal of Inorganic Biochemistry·C M MorrisJ A Edwardson
Jul 9, 1987·Neuroscience Letters·K MøllgårdN R Saunders
Jan 1, 1982·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·F LampreaveA Piñeiro
Apr 1, 1987·Brain Research Bulletin·B BlochA Kahn
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R MoroJ Uriel
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G J MarkelonisS R Max
Apr 15, 1981·Developmental Biology·K M DziegielewskaN R Saunders
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Dec 12, 2003·Obstetrical & Gynecological Survey·Gerald J Mizejewski
Feb 1, 1993·Neuropathology and Applied Neurobiology·K M DziegielewskaN R Saunders
Oct 1, 1995·Neuropathology and Applied Neurobiology·S AlbrechtT Pietsch
Oct 6, 2010·Cerebrospinal Fluid Research·Shane A LiddelowNorman R Saunders
Jul 16, 2010·Journal of Neurochemistry·Erica Polo-HernándezJosé M Medina
Mar 21, 2016·Journal of Neuropathology and Experimental Neurology·G R Wayne MooreMargaret M Esiri

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