PMID: 11332536May 3, 2001Paper

Immunohistochemical evidence for ATP receptors in human dental pulp

Journal of Dental Research
A M AlaviGeoffrey Burnstock

Abstract

Evidence is accumulating which supports a role for ATP in the initiation of pain by acting on P2X receptors, in particular P2X3, expressed on nociceptive afferent nerve terminals. To investigate whether this receptor plays a role in dental pain, we studied the presence and distribution of P2X3 receptors in human dental pulp, and their co-localization with other neural markers. Pulps were removed from extracted third molars and immunohistochemically stained with an antibody against P2X3 receptors. P2X3 immunoreactive (-ir) nerve fibers were detected in the main body of the pulp, in the sub-odontoblastic plexus of Raschkow, and within the odontoblastic area. Co-localization of the P2X3-ir neurons with neurofilament protein (NF) showed that the majority of the fibers were positive for both NF and P2X3. Double labeling with isolectin B4 (IB4) showed that all P2X3-ir neurons also bind IB4. We conclude that P2X3 receptors are present on both myelinated and unmyelinated nerve fibers in human dental pulp and may play a role in dental pain mechanisms.

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Citations

Nov 19, 2004·Histochemistry and Cell Biology·Huai Zhen RuanGeoffrey Burnstock
May 2, 2012·Purinergic Signalling·Karina Kaczmarek-HájekAnnette Nicke
Nov 5, 2003·Gastroenterology·Gregory WynnGeoffrey Burnstock
Mar 29, 2003·Archives of Oral Biology·V Marino, D A S Parker
Apr 3, 2001·Trends in Pharmacological Sciences·G Burnstock
Nov 9, 2002·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Jin Jiang, Jianguo Gu
Mar 31, 2009·Journal of Dental Research·R Ambalavanar, D Dessem
Dec 17, 2011·Journal of Dental Research·X LiuY F Ren
Jun 7, 2012·Journal of Dental Research·M-K ChungX Dong
Oct 9, 2012·Journal of Dental Research·J C Lim, C H Mitchell
Jul 9, 2005·BMC Oral Health·T RentonP Anand
Feb 9, 2007·Archives of Histology and Cytology·Shinji KataokaKuniaki Toyoshima
May 15, 2013·Molecular Pain·Elias UtrerasAshok B Kulkarni
May 5, 2009·Journal of Endodontics·Yun Sook KimYong Chul Bae
Jul 4, 2008·Neuroscience Letters·James E BiggsFiona M Boissonade
Apr 14, 2009·The Journal of Comparative Neurology·Anna M W TaylorAlfredo Ribeiro-da-Silva
Nov 18, 2006·Neuroscience·V StaikopoulosE A Jennings
Oct 18, 2005·Pharmacology & Therapeutics·Geoffrey Burnstock
Mar 26, 2013·European Journal of Pharmacology·Geoffrey Burnstock
Oct 21, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Amaury J PozosJose Perez
Jan 20, 2009·Brain Research Reviews·Christoph SteinRobert H Spencer
Dec 2, 2009·Molecular Pain·Geoffrey Burnstock
Apr 9, 2017·Journal of Endodontics·Tae Heon KimYong Chul Bae
Jul 2, 2015·Journal of Dental Research·X LiuR T Dirksen
Aug 21, 2013·Journal of Dental Research·G ChungS B Oh
Jul 27, 2014·Journal of Dental Research·O EgbuniweA D Grant
Feb 25, 2003·Journal of Endodontics·Ali BehniaMichael S Gold
Jan 30, 2019·International Journal of Molecular Sciences·Mohammad Zakir HossainJunichi Kitagawa
Dec 8, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Hai Ying LiSeog Bae Oh
Mar 24, 2016·Acta Histochemica Et Cytochemica·Erina IkedaTatsuo Kawamoto
Apr 13, 2007·Physiological Reviews·Geoffrey Burnstock
Mar 2, 2006·Pharmacological Reviews·Geoffrey Burnstock
May 11, 2019·International Journal of Molecular Sciences·Kihwan LeeGehoon Chung
Sep 21, 2020·Journal of Endodontics·Anibal Diogenes
Feb 12, 2020·Heliyon·Yuji SuzukiTsutomu Nakada
Jun 20, 2021·Archives of Oral Biology·Margaret R Byers, Dianne F Calkins

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