PMID: 6164715Dec 1, 1980Paper

Immunohistochemical evidence for the intracellular formation of basement membrane collagen (type IV) in developing tissues

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
G W LaurieG R Martin

Abstract

Antibodies to type IV collagen obtained from the basement membrane of the mouse EHS tumor were incubated with sections of rat incisor teeth and other tissues for immunostaining by direct or indirect methods. In all locations, the immunostaining was pronounced in basement membranes in which it was restricted to the "basal lamina" layer, from which "bridges" often extended to nearby basal laminae. Usually no immunostaining was detectable in the cells associated with the basement membranes. However, examination of the capillaries at the posterior extremity of the rat incisor tooth, where tissues are at an early stage of development, showed immunostaining not only of the basement membrane, but also of the endothelial cells. The staining was localized in rough endoplasmic reticulum cisternae, some Golgi saccules and their peripheral distensions, and structures believed to be secretory granules. These findings suggest that the synthesis of type IV collagen proceeds along the classical secretory pathways through rough endoplasmic reticulum and Golgi apparatus. At the same time, immunostaining was usually lacking in the cells of the capillaries that had migrated about 2 mm away from the posterior end of the incisor tooth and also in th...Continue Reading

Citations

Jun 1, 1994·Microscopy Research and Technique·H J Merker
May 1, 1991·The Journal of Cell Biology·M Desjardins, M Bendayan
Aug 1, 1984·The Journal of Cell Biology·R H KramerM A Karasek
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Sep 20, 2007·The Journal of Medical Investigation : JMI·Taro MutoTakafumi Noma
Dec 1, 1989·The Journal of Dermatology·H KobayashiA Ooshima
Jan 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G W Laurie, C P Leblond
Apr 1, 1987·The Anatomical Record·G T KittenD L Bolender
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Jan 1, 1983·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G W Laurie, C P Leblond

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