PMID: 8593262Nov 1, 1995Paper

Immunohistochemical evidence of alpha-, beta- and gamma 3-melanocyte stimulating hormone expression in cutaneous malignant melanoma of nodular type

Journal of Dermatological Science
P Y Liu, O Johansson

Abstract

Opiomelanocortins are formed after cleavage of the larger precursor molecule, proopiomelanocortin (POMC), which contains several peptide residues, sharing certain amino acid homology, including adrenocorticotrophic hormone (ACTH) and alpha-, beta- and gamma-melanocyte stimulating hormone (MSH). The expressions of alpha-, beta- and gamma 3-MSH in human cutaneous malignant melanoma of nodular type are demonstrated. For the MSHs, the immunolabelling was concentrated mostly in the tumour cellular cytoplasm, with occasional cells displaying a nuclear staining. Labelled tumour cells were dispersed throughout the epidermis and dermis as individual cells or in so-called 'pearl-like nests', most of which consisted mainly of round or oval shaped cells as well as a few pleomorphic or spindle-shaped cells. The fluorescence intensity seemed to increase in accordance with the development of the tumours. All cases examined were clearly stained with protein S-100, which provided us with a definite diagnosis. Considering the overall MSHs-related staining intensity of each section, the general perception we got was that the closer to the centre of the tumour parenchyma, the stronger was the staining and, furthermore the larger/more poorly differ...Continue Reading

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Citations

Apr 6, 1999·Pharmacology & Therapeutics·P Hersey
Jun 26, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·B LoirG Ghanem
Jul 31, 2009·The Journal of Biological Chemistry·Jung-hyun LeeEok-Soo Oh
Aug 21, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M KonoR Y Osamura
Jun 3, 2021·Cancers·Cristian ScheauConstantin Caruntu
Nov 9, 2005·Peptides·Paula C EvesJohn W Haycock

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