PMID: 2508016Oct 1, 1989Paper

Immunohistochemical evidence of measles virus antigens in active otosclerosis

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
M J McKenna, B G Mills

Abstract

Despite intensive investigation, the cause of otosclerosis remains uncertain. Recent studies of Paget's disease of bone have revealed a possible viral origin. Because of similarities between otosclerosis and Paget's disease, we have pursued investigation of a possible viral cause of otosclerosis. Four temporal bone specimens from patients with otosclerosis, processed for immunohistochemistry, demonstrated positive specific reactivity with monoclonal antibodies to measles virus antigens using the indirect immunofluorescent and immunoperoxidase techniques. Reactivity was most intense in active foci. Reactivity in the peroxidase assay was also observed in areas of acting otosclerosis with application of primary antisera from patients with subacute sclerosing panencephalitis, a disorder of the central nervous system in which a defective measles virus has been isolated. Other related paramyxoviruses, including mumps and respiratory syncytial virus, were negative, as were negative controls.

References

Oct 8, 1976·Science·B G Mills, F R Singer
Mar 1, 1983·The Annals of Otology, Rhinology, and Laryngology·T J YooA S Townes

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Citations

Oct 1, 1990·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·P A WackymP E Micevych
Nov 1, 1990·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·L J Bartels
Oct 20, 2001·The Annals of Otology, Rhinology, and Laryngology·H P NiedermeyerR Sedlmeier
Jul 9, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jeffrey T Vrabec, Newton J Coker
Jul 9, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Tamás KarosiIstván Sziklai
Dec 2, 2005·The Laryngoscope·Tamás KarosiIstván Sziklai
Aug 29, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Robert J CaugheyBradley W Kesser
Feb 1, 2008·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·H P Niedermeyer, W Arnold
Jan 1, 1991·Acta Oto-laryngologica. Supplementum·P A WackymP E Micevych
May 1, 1990·Acta Oto-laryngologica·M McKennaH Rask-Andersen
Jan 1, 1997·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·R DielerJ Helms
Apr 14, 1999·The Laryngoscope·F OhtaniS Fukuda
Apr 13, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·R A Chole, M McKenna
Oct 6, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·F R Singer
Nov 20, 2002·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Velanthapillai NandapalanUgo Fisch
Sep 5, 2003·Acta Oto-laryngologica·Alfio FerlitoJohn J Shea
Oct 5, 2006·British Journal of Hospital Medicine·M A Siddiq
Feb 13, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Tamás KarosiIstván Sziklai
Jun 24, 2009·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Melissa Thys, Guy Van Camp
Jun 1, 1992·Postgraduate Medicine·P S NassifH P House
Sep 25, 2020·Curēus·Prem Raj SagarBilal Haider Malik
Nov 8, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·S R LolovI R Kehayov
Aug 4, 2006·The Laryngoscope·Tamás KarosiIstván Sziklai
Apr 28, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Robert J PauwCor W R J Cremers
Feb 1, 2008·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Carlos A OliveiraMercedes F S Araújo
Aug 16, 2008·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Konstantinos Markou, John Goudakos
Sep 16, 2006·Current Opinion in Otolaryngology & Head and Neck Surgery·Konstantina M Stankovic, Michael J McKenna
Jul 19, 2006·Acta Oto-laryngologica·Tsagaan GantumurWolfgang Arnold
Jun 1, 2010·The Laryngoscope·Isabelle Schrauwen, Guy Van Camp
Aug 10, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Sebahattin CureogluMichael M Paparella
Jul 31, 2019·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Debara L Tucci, Joni K Doherty
Aug 10, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·John P MarinelliMatthew L Carlson
Apr 12, 2003·Clinical Otolaryngology and Allied Sciences·D J Menger, R A Tange
Oct 3, 2007·The Journal of Laryngology and Otology·C K HariG M Weiner
Jun 15, 2007·American Journal of Medical Genetics. Part a·Robert Jan PauwCor W R J Cremers
Jun 10, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Tamás Karosi, István Sziklai
May 15, 2001·Acta Oto-laryngologica·H P NiedermeyerR Sedlmeier
Nov 8, 2005·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Tamás KarosiIstván Sziklai
Dec 13, 2018·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Michael CromptonSally J Dawson
Sep 15, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·John P MarinelliMatthew L Carlson
Nov 18, 2020·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jonathan S ChoiJeffrey T Vrabec
Jul 6, 2000·Journal of Clinical Microbiology·A B GrayeliE Ferrary
Aug 29, 2006·American Journal of Otolaryngology·Sebahattin CureogluMichael M Paparella
Sep 10, 2021·Human Genetics·Lisse J M TavernierGuy Van Camp

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