PMID: 7547791Aug 1, 1995Paper

Immunohistochemical evidence of neuronal and glial differentiation in retinoblastoma

The British Journal of Ophthalmology
K P XuC Ni

Abstract

The study sought to investigate the histogenesis of retinoblastoma. One hundred specimens of retinoblastomas were examined along with those of 18 astrocytic gliomas and 15 medulloblastomas to compare similarities of glial differentiation in retinoblastoma and the two types of brain tumour. Employing avidin-biotin immunoperoxidase technique, antibodies were applied against neuron specific enolase (NSE), glial fibrillary acidic protein (GFAP), and S-100 protein (S-100). Most rosettes and fleurettes, and some undifferentiated cells in retinoblastomas were NSE positive, but GFAP and S-100 negative. GFAP and S-100 positive cells in retinoblastomas were detected mostly in well differentiated glial cells which were interpreted as reactive or non-neoplastic cells. Some of the GFAP and S-100 positive cells in retinoblastomas were defined as tumour cells that resembled neoplastic astrocytes in astrocytic gliomas and medulloblastomas. Retinoblastoma may arise from primitive bipotential or multipotential cells capable of neuronal and glial differentiation.

References

Jan 20, 1978·Science·D SchmechelF K Goodwin
Jul 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L F Eng, L J Rubinstein
Mar 1, 1990·The British Journal of Ophthalmology·J F Tarlton, D L Easty
May 15, 1987·American Journal of Ophthalmology·E PerentesV P Collins
May 1, 1985·Experimental Eye Research·J L CraftD M Albert
Mar 1, 1970·American Journal of Ophthalmology·M O Ts'oL E Zimmerman
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Mar 1, 1984·American Journal of Ophthalmology·M L MolnarG K Molnar
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·G TerenghiA Garner
May 1, 1981·Survey of Ophthalmology·J A Shields, J J Augsburger

❮ Previous
Next ❯

Citations

Apr 13, 2000·Cancer Control : Journal of the Moffitt Cancer Center·C E MargoZ D Mulla
May 17, 2000·Cancer Genetics and Cytogenetics·J DamjanovichM Balázs
Nov 26, 2002·The British Journal of Ophthalmology·S M ImhofA Y N Schouten-Van Meeteren
Mar 15, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Thomas MuleyPeter Drings
Jun 5, 2003·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Junki SawaiShoji Kishi
Aug 26, 1998·Survey of Ophthalmology·D M MarcusD M Albert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
W EbertP Drings
Journal of Pediatric Ophthalmology and Strabismus
E M HelvestonF D Ellis
© 2021 Meta ULC. All rights reserved