Abstract
The study sought to investigate the histogenesis of retinoblastoma. One hundred specimens of retinoblastomas were examined along with those of 18 astrocytic gliomas and 15 medulloblastomas to compare similarities of glial differentiation in retinoblastoma and the two types of brain tumour. Employing avidin-biotin immunoperoxidase technique, antibodies were applied against neuron specific enolase (NSE), glial fibrillary acidic protein (GFAP), and S-100 protein (S-100). Most rosettes and fleurettes, and some undifferentiated cells in retinoblastomas were NSE positive, but GFAP and S-100 negative. GFAP and S-100 positive cells in retinoblastomas were detected mostly in well differentiated glial cells which were interpreted as reactive or non-neoplastic cells. Some of the GFAP and S-100 positive cells in retinoblastomas were defined as tumour cells that resembled neoplastic astrocytes in astrocytic gliomas and medulloblastomas. Retinoblastoma may arise from primitive bipotential or multipotential cells capable of neuronal and glial differentiation.
References
Dec 21, 1978·Nature·D SchmechelM Brightman
Jan 20, 1978·Science·D SchmechelF K Goodwin
Jul 1, 1978·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L F Eng, L J Rubinstein
Dec 15, 1992·Cancer·W HeH Inomata
Mar 1, 1990·The British Journal of Ophthalmology·J F Tarlton, D L Easty
Aug 1, 1989·Histopathology·S ShuangshotiV Kasantikul
May 15, 1987·American Journal of Ophthalmology·E PerentesV P Collins
Jan 1, 1985·Ophthalmology·E P MessmerW Höpping
May 1, 1985·Experimental Eye Research·J L CraftD M Albert
Mar 1, 1970·American Journal of Ophthalmology·M O Ts'oB S Fine
Mar 1, 1970·American Journal of Ophthalmology·M O Ts'oL E Zimmerman
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Mar 1, 1984·American Journal of Ophthalmology·M L MolnarG K Molnar
Feb 1, 1983·American Journal of Ophthalmology·J C Lane, G K Klintworth
Aug 13, 1984·Brain Research·T NakajimaK Kato
Jan 1, 1984·Virchows Archiv. A, Pathological Anatomy and Histopathology·G TerenghiA Garner
May 1, 1981·Survey of Ophthalmology·J A Shields, J J Augsburger
Citations
Apr 13, 2000·Cancer Control : Journal of the Moffitt Cancer Center·C E MargoZ D Mulla
May 17, 2000·Cancer Genetics and Cytogenetics·J DamjanovichM Balázs
Nov 26, 2002·The British Journal of Ophthalmology·S M ImhofA Y N Schouten-Van Meeteren
Mar 15, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Thomas MuleyPeter Drings
Jun 5, 2003·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Junki SawaiShoji Kishi
Aug 26, 1998·Survey of Ophthalmology·D M MarcusD M Albert