Immunohistochemical evidence of neurons with GHRH or LHRH in the arcuate nucleus of male mice and their possible role in the postnatal development of adenohypophysial cells

The Anatomical Record
F SasakiM Ohta

Abstract

The neonatal administration of monosodium L-glutamate (MSG) has been used in investigations of the possible role of the arcuate nucleus in neuroendocrine regulation during postnatal development. We used this method to examine whether the mouse arcuate contained cell bodies immunoreactive with antisera to growth hormone releasing hormone (GHRH) or luteinizing hormone releasing hormone (LHRH), and whether these hypothalamic peptides affect synthesis and secretion of growth hormone and gonadotropin and the testis. The hypothalamus, pituitary, and testes of adult male mice treated with MSG during the neonatal period were fixed in Bouin's fluid or 10% neutral formalin. The hypothalamus was used in immune staining, the pituitary was used in both morphometry and immune staining, and the testis was stained with hematoxylin and eosin. Body weights in control and treated mice were not different. The treated mice had more subcutaneous adipose tissue and a shorter body than the control mice. The testes were heavier in the controls. Many perikarya immunoreactive with antisera to GHRH or LHRH were found in the arcuate nucleus in control mice, but few such perikarya were found in this nucleus in treated mice. The size of the anterior lobe and...Continue Reading

References

Jan 1, 1971·Neuroendocrinology·T W ReddingI Wakabayashi

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Citations

May 2, 2001·The Journal of Comparative Neurology·S E PérezE J Mufson
Dec 11, 2007·Molecular and Cellular Endocrinology·R E BrownM Wilkinson
Sep 24, 2014·Brain Research·Mina DesaiMichael G Ross
Jun 2, 2018·Journal of Developmental Origins of Health and Disease·C F F CoelhoA M A Paes
Sep 5, 2002·FEBS Letters·Barbara A MorashMichael Wilkinson
Jun 30, 1998·Endocrinology·A IkedaM Takahashi
Aug 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Corinna SchoelchBarbara Nuesslein-Hildesheim

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