PMID: 7528060Aug 1, 1994Paper

Immunohistochemical examination of neural cell adhesion molecule (NCAM), tenascin and fibronectin on the development of cartilaginous tissue in canine mammary mixed tumors

The Journal of Veterinary Medical Science
K AraiK Uehara

Abstract

The expression of neural cell adhesion molecule (NCAM), tenascin and fibronectin during cartilage-like tissue formation in canine mammary mixed tumor was immunohistochemically examined. Mirror-image serial sections revealed that proliferating myoepithelial cells simultaneously expressed these adhesion molecules where no cartilage-like tissue and no expression of cartilage-specific type II collagen were observed. With the formation of cartilaginous tissue, positive signals of these adhesion molecules decreased in chondroblast-like cells, the cartilaginous tissue was hyalinized and mature chondrocyte-like cells no longer expressed these cell adhesion molecules. NCAM, tenascin and fibronectin, therefore, may play crucial roles on the proliferation of myoepithelial cells and the subsequent development of cartilaginous tissue in canine mammary mixed tumor.

Citations

Aug 5, 2008·Journal of Comparative Pathology·H AupperleH-A Schoon
Jan 30, 2002·Journal of Comparative Pathology·A M R FaustinoH Nederbragt
Apr 29, 2014·Gene Expression Patterns : GEP·Carlos I Lorda-DiezJuan A Montero
Nov 30, 2012·Veterinary Medicine International·Geovanni Dantas CassaliCecília Bonolo de Campos
Feb 26, 2014·Veterinary Pathology·H YoshimuraK Takahashi
Aug 12, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A Stoker, R Dutta
Sep 5, 2002·Research in Veterinary Science·S Mukaratirwa, H Nederbragt

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