Immunohistochemical expression and localization of somatostatin receptor subtypes in prostate cancer with neuroendocrine differentiation

International Journal of Immunopathology and Pharmacology
Doriana MorichettiRodolfo Montironi

Abstract

The aim of the study is to examine the tissue expression and localization of the somatostatin receptors (SSTRs) in prostate cancer (PCa) with neuroendocrine (NE) differentiation. The five SSTR subtypes (SSTR1 to 5) were evaluated immunohistochemically in the secretory cells of normal-looking epithelium (Nep), high-grade prostatic intraepithelial neoplasia (HGPIN) and PCa in 20 radical prostatectomies (RPs) with Gleason score 3+3=6 acinar PCa; 20 RPs with GS 4+4=8 and 4+5=9 PCa; and 20 RPs with PCa with NE differentiation. The basal cells were evaluated in Nep and HGPIN. In all groups the stromal smooth muscle and endothelial cells were also analyzed. Concerning the secretory cells, (i) the greatest mean proportions of cells with strong cytoplasmic staining in PCa were seen for SSTR2, mainly in the group of RP with NE differentiation, and for SSTR4 in all three groups; the mean values in HGPIN were intermediate between Nep and PCa; (ii) Membrane staining was seen for SSTR3 and SSTR4; the mean percentages of positive cells, higher in SSTR3 than in SSTR4, decreased from Nep to HGPIN and PCa in all three RP groups; in the latter two, the mean percentages were similar; and (iii) Nuclear staining was seen with SSTR4 and SSTR5; for SS...Continue Reading

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Citations

Dec 15, 2010·Asian Journal of Andrology·Roberta MazzucchelliRodolfo Montironi
Nov 8, 2018·Endocrine-related Cancer·Martin K BakhtLisa A Porter
Feb 13, 2020·Abdominal Radiology·Stephanie M WalkerBaris Turkbey
Sep 14, 2012·The Journal of International Medical Research·Y XuB Wu
Mar 9, 2021·Clinical Genitourinary Cancer·Amir IravaniRodney J Hicks

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