Immunohistochemical expression and prognostic relevance of Bmi-1, a stem cell factor, in epithelial ovarian cancer

Annals of Diagnostic Pathology
Amal Abd El hafez, Hend Ahmed El-Hadaad

Abstract

Ovarian cancer is the fourth most common cause of cancer-related death in women. Bmi-1 is a stem cell factor implicated in many human malignancies with poor outcome. Few published reports on the expression of Bmi-1 in epithelial ovarian cancer were either experimental or performed on cell lines. This study evaluates the immunohistochemical expression of Bmi-1 protein in epithelial ovarian cancer tissue specimens and its relevance to the clinicopathologic prognostic variables and patient survival. Forty cases of epithelial ovarian cancer were selected according to the availability of paraffin-embedded tissue and the clinicopathologic and survival data. Immunohistochemistry was performed for anti-Bmi-1 antibody. Low and high Bmi-1 expression groups were compared with age, tumor stage, laterality, grade, histology, and patient survival. Bmi-1 expression was detected in 72.5% of cases, of which 42.5% had high expression. High Bmi-1 expression strongly associated with advanced International Federation of Gynecology and Obstetrics stages (P = .007), bilaterality (P = .01), and higher Gynecologic Oncology Group grades (P = .031) and carcinomas of serous histology (P = .027). It had no association with patient age. Bmi-1 expression dis...Continue Reading

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Citations

May 17, 2014·World Journal of Gastroenterology : WJG·Yan ZhangXiao Chen
Sep 5, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Soo Hee KimSun Och Yoon
Mar 9, 2017·Molecular Cancer·Soumyajit Banerjee MustafiResham Bhattacharya
Mar 28, 2017·Cancer Biology & Therapy·Xun TianDing Ma
Sep 11, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Soumyajit Banerjee MustafiResham Bhattacharya
Sep 19, 2018·Cancer Biomarkers : Section a of Disease Markers·Jun LiangRu-Tong Yu
May 31, 2018·Cancer Biomarkers : Section a of Disease Markers·De-Qiang MaKang-Jian Ao
Jul 3, 2021·International Journal of Molecular Sciences·Ludmila LozneanuCornelia Amalinei

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