Immunohistochemical expression of ARID1A in penile squamous cell carcinomas: a tissue microarray study of 112 cases

Human Pathology
Sheila F FarajGeorge J Netto

Abstract

ARID1A, a member of the chromatin remodeling genes family, has been suggested as a novel tumor suppressor gene in gynecologic malignancies. However, its role in penile cancer has yet to be determined. This study assesses the immunohistochemical expression of ARID1A in penile squamous cell carcinoma (SCC) and its association with pathologic features, human papillomavirus (HPV) status, and previously reported mammalian target of rapamycin pathway markers in the same cohort. Four tissue microarrays were constructed from 112 cases of formalin-fixed, paraffin-embedded penile SCC from Paraguay. Each tumor was sampled 3 to 12 times. ARID1A expression was evaluated by immunohistochemistry using a polyclonal rabbit anti-ARID1A (BAF250A) antibody. An H score was calculated in each spot as the sum of expression intensity (0-3+) by extent (0%-100%). Median H score per case was used for statistical analysis. ARID1A expression was observed in all cases, ranging from 3% to 100% of tumor cells (median, 95%). In 96 cases (86%), ARID1A expression was observed in 90% or more tumor cells. HPV DNA was detected in 20 (38%) of 52 analyzed samples. There was a significant trend of association between ARID1A and histologic grade. ARID1A expression was ...Continue Reading

References

Jan 22, 2005·Critical Reviews in Oncology/hematology·Anna Maria MosconiChristine Theodore
Oct 22, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Robert L CampDavid L Rimm
Feb 19, 2010·European Urology·Giorgio PizzocaroUNKNOWN European Association of Urology (EAU) Guidelines Group on Penile Cancer
Aug 19, 2010·Urology·Alcides ChauxAntonio L Cubilla
Mar 18, 2011·The American Journal of Surgical Pathology·Bin GuanIe-Ming Shih
Oct 20, 2011·Human Mutation·Siân JonesNickolas Papadopoulos
Dec 14, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sohei YamamotoOsamu Matsubara
Jan 26, 2012·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Atsuko KatagiriKohji Miyazaki
May 19, 2012·Human Pathology·Alcides Chaux, Antonio L Cubilla
Dec 5, 2012·Cancer Discovery·Jennifer N Wu, Charles W M Roberts
Jan 25, 2014·Journal of Gynecologic Oncology·Yoshihito YokoyamaHideki Mizunuma
Jun 6, 2014·Journal of the National Cancer Institute·Bin GuanIe-Ming Shih

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Citations

Jun 5, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zixi ZhangShuzhong Guo

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