Immunohistochemical Expression of CDC7 in Dentigerous Cyst, Odontogenic Keratocyst and Radicular Cyst

Acta Medica (Hradec Králové)
Zohreh Jaafari-AshkavandiSepideh Assar

Abstract

CDC7 is a serine/threonine kinase which has an essential role in initiation of DNA proliferation and S phase. It increases the invasion and proliferation in many pathologic lesions. This study aimed to evaluate the expression of CDC7 in the most common odontogenic cysts. We evaluated 17 dentigerous cysts, 18 odontogenic keratocysts (OKC) and 13 radicular cysts immunohistochemically. The mean expression of CDC7 was analyzed using ANOVA and Post-HOC methods. All specimens revealed CDC7 expression. Higher expression of CDC7 in OKC and radicular cyst was shown in comparison to dentigerous cyst (P < 0.001), while radicular cyst and OKC groups showed no difference in CDC7 expression (P = 0.738). The high expression of CDC7 in OKC suggests that this protein could be related to the higher proliferation rate and invasiveness of OKC. On the other hand, the higher CDC7 expression in radicular cyst may simply be related to inflammation as this cyst is neither aggressive nor invasive.

References

Oct 26, 2006·The Journal of Biological Chemistry·Pierluigi TencaCorrado Santocanale
Feb 8, 2008·Journal of Molecular Histology·Clarissa Araújo Silva GurgelJean Nunes dos Santos
Aug 21, 2008·Neoplasia : an International Journal for Oncology Research·Dorine BonteMichael Weinreich
Mar 13, 2009·Journal of Cutaneous Pathology·Loren E ClarkeKlaus F Helm
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anjana A KulkarniGareth H Williams
Jun 1, 2010·Journal of Maxillofacial and Oral Surgery·Chandrashekhar R BandeP K Pandilwar
Jun 21, 2012·Brazilian Oral Research·Manickam SelvamaniPraveen Shivappa Basandi
Aug 21, 2013·Journal of Pharmacy & Bioallied Sciences·Karthik Rajaram MohanHaritha Doraiswamy
Jan 11, 2014·The Clinical Respiratory Journal·Savas OzsuTevfik Ozlu
Jul 1, 2015·International Journal of Clinical Pediatric Dentistry·Gagandeep Lamba, G R Ravi
Sep 5, 2015·Ghana Medical Journal·F O OmoregieA M Ojo
Nov 16, 2016·International Journal of Clinical Pediatric Dentistry·Bindu BhardwajKomal Rastogi

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