Immunohistochemical expression of CXCR4 in thyroid carcinomas and thyroid benign lesions

Pathology, Research and Practice
Xin HeGuang Ning

Abstract

In different tumor entities, expression of the chemokine receptor 4 (CXCR4) has been linked to tumor dissemination and poor prognosis. The aim of this study was to examine the immunohistochemical expression of CXCR4 in thyroid carcinomas and thyroid benign lesions. Using monoclonal anti-CXCR4 antibody, we performed immunohistochemical staining on tissue sections from 134 cases obtained from Ruijin Hospital affiliated with Shanghai Jiaotong University School of Medicine (Shanghai, China) between 2000 and 2007. In our study, the CXCR4 expression of the thyroid carcinoma group (including 16 papillary thyroid carcinomas, 18 follicular thyroid carcinomas, 9 poorly differentiated thyroid carcinomas, and 7 medullary thyroid carcinomas) was found to be higher than in the benign lesion group (including 19 cases of Hashimoto's thyroiditis, 15 nodular goiters, and 50 follicular adenomas) (p<0.0001). Within the carcinoma group, the more malignant thyroid carcinoma group (including 9 poorly differentiated thyroid carcinomas and 7 medullary thyroid carcinomas) showed a higher ratio of CXCR4 positivity compared to the less malignant thyroid carcinoma group (including 16 papillary thyroid carcinomas and 18 follicular thyroid carcinomas) (p<0.0...Continue Reading

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Citations

Sep 13, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Liborio TorregrossaFulvio Basolo
Mar 24, 2012·Journal of Surgical Oncology·Guennadi Kouniavsky, Martha A Zeiger
Sep 18, 2016·Journal of Cancer Research and Clinical Oncology·Arezoo RastiZahra Madjd
Jan 10, 2018·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yuanqiang LinHui Wang
Jun 30, 2012·Chemical Society Reviews·Joeri KuilFijs W B van Leeuwen
Dec 12, 2020·Nuclear Medicine Communications·Korrakode SirakriengkraiUsanee Techavijit

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