Immunohistochemical expression of endoglin offers a reliable estimation of bone marrow neoangiogenesis in multiple myeloma

Journal of Cancer Research and Clinical Oncology
M G AlexandrakisG Tsirakis

Abstract

The aim of the present study was to evaluate CD105 tissue marker in the bone marrow (BM) of multiple myeloma (MM) patients. CD105 was evaluated using immunohistochemical method. An effort was made to correlate this marker with BM microvascular density (MVD) along with other known markers of angiogenesis in order to evaluate its clinical significance. BM MVD was estimated by CD31. CD105 in BM was estimated by immunohistochemical method in 54 newly diagnosed patients with MM. Circulating levels of known angiogenic factors such as basic fibroblast growth factor (b-FGF) and soluble CD105 (sCD105) were measured by ELISA in the same group of patients. All these factors were also measured in 20 age- and sex-matched healthy controls. We found that CD105 MVD, along with the expected CD31 MVD, and serum levels of sCD105 and bFGF were increased, also in parallel with disease stage, and all were decreased after effective treatment. Moreover, CD105 MVD correlated with all the aforementioned markers of angiogenesis. Our results indicated that CD105 MVD is following the behavior of CD31 MVD in MM, suggesting being a valid marker of BM neoangiogenesis in MM. Its prognostic impact remains to be proven.

References

Jul 1, 1994·British Journal of Haematology·A VaccaF Dammacco
May 31, 2001·European Journal of Haematology·O SezerK Possinger
Nov 20, 2002·British Journal of Haematology·Shaji KumarS Vincent Rajkumar
May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Sarah E DuffShant Kumar
Jul 29, 2004·Journal of Clinical Pathology·M G AlexandrakisE N Stathopoulos
Nov 24, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Michael G AlexandrakisEfstathios Stathopoulos
Oct 24, 2006·Journal of Cellular Physiology·Juan F SantibanezCarmelo Bernabeu
Jan 27, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jens HillengassThomas M Moehler
Sep 19, 2008·International Journal of Cancer. Journal International Du Cancer·Victor Chun Lam WongMaria Li Lung
Jul 18, 2009·Biochimica Et Biophysica Acta·Carmelo BernabeuMiguel Quintanilla
Oct 29, 2010·Clinical & Experimental Metastasis·Minalini LakshmanRaymond C Bergan
Nov 17, 2011·International Journal of Hematology·Eléonore OtjacquesJo Caers
May 9, 2012·European Journal of Internal Medicine·G TsirakisM G Alexandrakis
Mar 2, 2013·Cytometry. Part B, Clinical Cytometry·Wenli ZhengSa A Wang

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Citations

Nov 5, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Sarah Grace PriyadarshiniT K Dutta
Nov 3, 2015·Leukemia Research·M KokonozakiM G Alexandrakis
Jun 28, 2016·Calcified Tissue International·Michelle M McDonaldMichaela R Reagan

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