PMID: 2508310Jan 1, 1989Paper

Immunohistochemical expression of epidermal growth factor receptor in salivary gland tumours

Virchows Archiv. A, Pathological Anatomy and Histopathology
K YamadaM Mori

Abstract

Immunohistochemical localization of epidermal growth factor receptor (EGFR) in normal salivary glands and tumours (108 cases) was studied using a monoclonal antibody. In the normal salivary glands, EGFR was occasionally detected in ductal segments of intercalated, striated, and excretory ducts, but not in acinar cells. The frequency of positive EGFR staining in salivary gland tumours was not high: pleomorphic adenoma, 33.8%; mucoepidermoid tumour, 25.0%; adenolymphoma, 44.4%; and sialoadenocarcinoma, 66.6%. Pleomorphic adenomas showed positive staining for EGFR on the luminal side of luminal cells and in squamous metaplastic cells of tumour tissue. Some modified myoepithelial cells were also reactive whereas outer spindle tumour cells were unstained. Adenolymphomas regularly exhibited positive EGFR staining in the cell membrane; mucoepidermoid carcinoma displayed positive staining in cell membranes in epidermoid tumour cells and cytoplasmic staining in mucous-secreting tumour cells. Sialocarcinomas revealed cell membrane staining and whole cytoplasmic staining for EGFR. The immunohistochemical localization of EGFR could be classified into two types, one the cell membrane-positive type found in epithelial tumour cells, and the s...Continue Reading

References

Jan 1, 1979·Annual Review of Biochemistry·G Carpenter, S Cohen
May 1, 1986·The Journal of Pathology·B OzanneB Gusterson
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·P MöllerH F Otto
Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·G ReifenbergerW Wechsler
Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·M MoriK Kato
Mar 15, 1987·International Journal of Cancer. Journal International Du Cancer·S OzawaN Shimizu
Aug 1, 1987·The Journal of Pathology·M S BergerM D Waterfield
Apr 1, 1985·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A G KasselbergM T Stahlman
Aug 1, 1984·The Journal of Clinical Investigation·F J Hendler, B W Ozanne
Aug 1, 1984·Cell Biology International Reports·B GustersonB Ozanne
Jan 1, 1982·Journal of Cellular Biochemistry·M D WaterfieldB Ozanne
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J HapgoodJ Schlessinger
Aug 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T Barka

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Citations

Oct 1, 1998·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·G C Sahoo
Jul 1, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ricardo S MacarencoMarie-Christine Aubry
Mar 11, 2003·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Eleni KatopodiStavros Papanicolaou
Oct 1, 1991·Clinical Otolaryngology and Allied Sciences·M MiyaguchiH B Hellquist
Feb 1, 1993·Clinical Otolaryngology and Allied Sciences·J A WilsonA G Maran
Nov 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P ShresthaM Mori
Aug 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·P ShresthaM Mori
Sep 1, 1991·Journal of Periodontal Research·C R IrwinM W Ferguson
Feb 21, 2007·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Saori Matsubayashi, Toshio Yoshihara
Jun 15, 2012·Oral Oncology·Till Sebastian ClauditzWaldemar Wilczak
Jun 12, 2008·Seminars in Oncology·Sujani G Surakanti, Mark Agulnik
Feb 13, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Cristiane FuruseVera Cavalcanti de Araújo
Jun 15, 2011·Pathology·Till Sebastian ClauditzWaldemar Wilczak
Jan 18, 2007·Expert Opinion on Therapeutic Targets·Mark Agulnik
Apr 29, 2014·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Andrés Coca-PelazAlfio Ferlito
Apr 14, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Bernard TandlerCarleton J Phillips
Dec 10, 2020·Wiener klinische Wochenschrift·Hossein TaghizadehGerald W Prager
Dec 5, 1997·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·Y IkematsuK Kazakoff
Jan 1, 1996·Pathology, Research and Practice·S Sunardhi-Widyaputra, B Van Damme

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