Immunohistochemical expression of fibroblast growth factor (FGF)-2 in epilepsy-associated malformations of cortical development (MCDs)

Neuropathology : Official Journal of the Japanese Society of Neuropathology
Chitose SugiuraKousaku Ohno

Abstract

To elucidate the biological significance of dysplastic cells in malformations of cortical development, an immunohistochemical study was performed to investigate fibroblast growth factor-2 (FGF-2) expression in corticectomy specimens from epilepsy patients, including focal cortical dysplasia (FCD) with balloon cells (BCs) (n=4; age/sex=2M, 14F, 24M, 45M), tubers of tuberous sclerosis complex (TSC-tubers) (n=2; 1F, 3F), FCD without BCs (n=3; 23F, 23M, 25M), and gliotic lesions (n=3; 12M, 25M, 29M). The nucleus and/or cytoplasm of astrocytes in all cases examined were positive for FGF-2; however, FGF-2 immunoreactivity was not detected in oligodendroglial cells. In all dysplastic lesions, FGF-2 was detected in the astrocytic nuclei, and cytoplasm and/or nuclei of BCs. Dysplastic neurons (DNs) in FCD with BCs and TSC-tubers were variably positive for FGF-2 in the cytoplasm, but FGF-2 was not detected in the neurons of FCD without BCs. The number of FGF-2 immunoreactive cells (FGF-2-IR%) in FCD with BCs (46.0+/-4.1%) was higher than that in FCD without BCs (19.8+/-3.1%) and gliotic lesions (19.5+/-3.3%) with statistical significance (P<0.001). These results, together with previous reports showing FGF-2 expression in neuroblasts and ...Continue Reading

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Citations

Mar 9, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Manami UedaHajime Miyata
Mar 28, 2013·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hajime MiyataHarry V Vinters
Mar 19, 2014·Neuroscience Letters·Satoru SakumaHiroshi Otsubo
Jan 11, 2011·Seizure : the Journal of the British Epilepsy Association·Gang LiHajo M Hamer
Oct 14, 2018·Journal of Neuroscience Research·Rogger P Carmen-OrozcoManuela Renee Verástegui

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