Immunohistochemical expression of glutathione S-transferase placental type (GST-pi), a detoxifying enzyme, in normal arachnoid villi and meningiomas

Virchows Archiv. A, Pathological Anatomy and Histopathology
A HaraH Mori

Abstract

Human normal dura mater containing arachnoid villi were examined for their expression of glutathione S-transferase placental type (GST-pi), a detoxifying enzyme, using an immunohistochemical method. All of the arachnoid villi and arachnoid cells in five normal cases were found to have expression of GST-pi, although no positive reaction for the enzyme was present in other tissues of the dura mater. The results show a possible role for arachnoid tissues in protecting human brain from hazardous xenobiotics in the cerebrospinal fluid. Twenty-six meningiomas were also examined for expression of the enzyme. Tissues of meningotheliomatous meningiomas were always positive for expression of the enzyme. Transitional meningiomas also showed the expression in their meningotheliomatous components. No staining reaction of GST-pi was recognized in fibroblastic meningiomas except for two cases with a tendency to meningotheliomatous differentiation. The findings suggest a functional similarity between the arachnoid tissues and meningotheliomatous components of meningiomas.

References

Jul 15, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·N TateokaK Sato
Feb 1, 1988·Carcinogenesis·C Di IlioG Federici
May 1, 1988·Japanese Journal of Cancer Research : Gann·K Sato

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Citations

Oct 16, 2018·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Cahit KuralYusuf Izci

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