PMID: 8590371Jun 1, 1995Paper

Immunohistochemical expression of glutathione S-transferase pi (GST-pi) and chemotherapy response in malignant ovarian tumors

The Journal of Obstetrics and Gynaecology
K HirazonoK Kawai

Abstract

To clarify the relationship between the expression of GST-pi and the therapeutic effects of high-dose combination chemotherapy with support by autologous bone-marrow transplantation (ABMT). Expression of GST-pi in tissue specimen were analyzed by indirect immunoperoxidase methods using anti-GST-pi polyclonal antibody. (1) Eighteen of 36 cases (50%) tested prior to administration of any chemotherapeutic agents were found to be positive in terms of immunohistochemical expression of GST-pi in the cancer cells. (2) The rate of GST-pi expression was elevated following administration of cisplatin, adriamycin, and cyclophosphamide, which suggests that administration of such anti-cancer agents is capable of inducing expression of GST-pi in cancer cells. (3) GST-pi negative patients exhibit better survival rates than do GST-pi positive patients (Kaplan Meier method: p < 0.001). Analysis of GST-pi obtained at primary surgery can serve as a valid marker in anticipating chemotherapeutic effects and long-term prognoses.

References

Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·K H CowanC E Myers

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Citations

Feb 15, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ping YangWanguo Liu
Jun 1, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·T SatohT Kubo
Feb 19, 2000·The Journal of Obstetrics and Gynaecology Research·Y YokoyamaY Saito
Apr 17, 2004·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R E J HowellsR C Strange
Dec 17, 2003·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·K IkedaN Sakuragi
Jan 24, 2003·Expert Opinion on Therapeutic Targets·Laurent Gaté, Kenneth D Tew
Apr 19, 2013·Journal of Cancer Research and Clinical Oncology·Linjuan XuZehua Wang
Dec 9, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tatsuro KatahiraYoshiro Niitsu

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