Immunohistochemical expression of pituitary tumor transforming gene (PTTG) in pituitary adenomas: a correlative study of tumor subtypes

International Journal of Surgical Pathology
Fateme SalehiMichael Cusimano

Abstract

We investigated the correlation between immunohistochemical expression of the pituitary tumor transforming gene (PTTG) and pituitary adenoma subtype. Pituitary adenomas (n = 89) were stained for PTTG using the streptavidin-biotin-peroxidase complex method and a monoclonal PTTG antibody. PTTG staining was found to be cytoplasmic with a pronounced paranuclear expression pattern. Reactivity was highest in growth hormone (GH) adenomas as compared with other tumors, including prolactin (PRL), follicle-stimulating hormone/luteinizing hormone/alpha subunit, as well as adrenocorticotrophic hormone-secreting adenomas. PRL adenomas exhibited the lowest expression levels. Among GH adenomas, untreated tumors demonstrated significantly higher PTTG levels than octreotide-treated examples. Although dopamine agonist-treated PRL adenomas tended to show lower expression levels, statistical significance was not reached. Our finding that PTTG was differentially expressed in pituitary adenoma subtypes suggests a cell-specific function for PTTG. Moreover, treatment of GH adenomas with somatostatin analogues lowered PTTG expression. Further investigation into mechanisms mediating cell-specific expression of PTTG is warranted.

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Citations

Feb 14, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wang JiaZhiqing Xu
Mar 22, 2014·Journal of Molecular Endocrinology·Daniel Cuevas-Ramos, Maria Fleseriu
Jun 9, 2014·Clinical Neurology and Neurosurgery·Hengzhu ZhangAij-Lie Kwan
Sep 14, 2010·Best Practice & Research. Clinical Endocrinology & Metabolism·Silvia VandevaAlbert Beckers
Nov 22, 2011·European Journal of Clinical Investigation·Dorota Dworakowska, Ashley B Grossman
Jul 14, 2010·Biochemical and Biophysical Research Communications·Xu-Liang ShenFang-Ping Chen
Nov 21, 2014·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Paulo Henrique GonzalesMiriam da Costa Oliveira
Oct 23, 2020·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Hande Mefkure OzkayaPinar Kadioglu
Jun 4, 2019·Annals of Diagnostic Pathology·Geraldine TrottJulia Fernanda Semmelmann Pereira-Lima

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