Immunohistochemical expression of proinflammatory enzyme COX-2 and p53 in ulcerative colitis and its associated dysplasia and colorectal carcinoma

Journal of Microscopy and Ultrastructure
Nehal Mohamed ElmashadAbd El Motaleb Mohamed

Abstract

Ulcerative colitis (UC) patients are at increased risk for colorectal carcinoma (CRC). It is suggested that cyclooxygenase-2 (COX-2) plays a role in sporadic CRC. The p53 gene is a tumor-suppressor gene and the most frequent site of genetic alteration found in human cancer. The aim of this study was to analyze the immunoexpression of proinflammatory enzyme COX-2 and p53 in UC, UC-associated dysplasia, and CRC, in comparison with each other and with different clinical and histopathological parameters, to clarify if they have a possible role in the pathogenesis of CRC in UC patients. In this cross-sectional study, 98 patients were divided into three groups: 39 patients with UC without dysplasia, 32 patients with UC with dysplasia, and 27 patients with colorectal cancer on top of UC, in addition to 10 healthy controls. All patients underwent colonoscopy, and multiple biopsies were taken for histopathological and COX-2 and p53 immunohistochemical studies. There was significant difference in the expression of COX-2 and p53 in UC-related dysplasia either without or with CRC, compared with their expression in the UC group without dysplasia. Adding immunohistochemical analysis of COX-2 enzyme and p53 gene to routine histological assess...Continue Reading

References

Sep 7, 1995·The New England Journal of Medicine·E GiovannucciF E Speizer
Oct 1, 1993·The British Journal of Surgery·D Goodman, T T Irvin
Apr 10, 1999·The Journal of Biological Chemistry·K SubbaramaiahA J Dannenberg
Sep 8, 2000·The Australian and New Zealand Journal of Surgery·C J YoungA Hunter
Sep 12, 2000·The American Journal of Pathology·S N AgoffM P Bronner
Jan 25, 2003·The American Journal of Medicine·Sunanda KaneStephen Hanauer
May 29, 2004·Gastroenterology·Steven H Itzkowitz, Noam Harpaz
Aug 3, 2004·Nature Medicine·Bert Vogelstein, Kenneth W Kinzler
Sep 24, 2004·World Journal of Surgery·Fernando Gonzalez-HermosoVincente Medina-Arana
Nov 13, 2004·Applied Immunohistochemistry & Molecular Morphology : AIMM·Karen CurtinWade S Samowitz
Jan 8, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrew J DannenbergRaymond N DuBois
Apr 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joanne R Brown, Raymond N DuBois
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shahar Lev-AriNadir Arber
Nov 18, 2006·The Journal of Biological Chemistry·Ying YuColin D Funk
Jul 20, 2007·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Constantine J KarvellasClarence K W Wong
Jul 27, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·A P R PaiottiM Franco
Oct 2, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Michael D KappelmanJonathan A Finkelstein
Jan 18, 2008·World Journal of Gastroenterology : WJG·Jianlin Xie, Steven H Itzkowitz
Jun 24, 2008·Pathology, Research and Practice·A RoessnerR Schneider-Stock
Jul 16, 2008·Gastroenterology·Eva S SchernhammerCharles S Fuchs
Jan 14, 2010·The American Journal of Gastroenterology·Asher KornbluthUNKNOWN Practice Parameters Committee of the American College of Gastroenterology
Jun 1, 2010·Journal of Surgical Oncology·Mahmoud N Kulaylat, Merril T Dayton
Jul 30, 2010·International Journal of Colorectal Disease·Salaheddin VajiKeyvan Aminian
Sep 16, 2010·Free Radical Biology & Medicine·Simone ReuterBharat B Aggarwal
Sep 18, 2010·Inflammatory Bowel Diseases·Toshiaki WatanabeUNKNOWN Japanese Society for Cancer of the Colon and Rectum
Sep 30, 2010·Inflammatory Bowel Diseases·Kelvin T ThiaWilliam J Sandborn
May 3, 2011·Gastroenterology·Thomas A Ullman, Steven H Itzkowitz
May 28, 2011·Inflammatory Bowel Diseases·Julian A SanchezMatthew F Kalady
Oct 9, 2012·Journal of Crohn's & Colitis·Gert Van AsscheUNKNOWN European Crohn's and Colitis Organisation
Mar 5, 2013·Archives of Pathology & Laboratory Medicine·Kristina A MatkowskyjGuang-Yu Yang

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