Immunohistochemical expression of somatostatin type 2A receptor in neuroendocrine carcinoma of uterine cervix

Archives of Gynecology and Obstetrics
Hiroshi KajiwaraRobert Yoshiyuki Osamura

Abstract

Somatostatin and its analogues inhibit the growth of various kinds of endocrine and exocrine cells via the somatostatin receptor (SSTR). Expression of SSTR2A has been reported in many well-differentiated neuroendocrine tumors and small numbers of poorly differentiated neuroendocrine carcinomas. SSTR2A-positive neuroendocrine tumors may be treatable by SS analogues. Uterine cervical neuroendocrine carcinoma is generally associated with poor prognosis. We examined the expression of SSTR2A and other neuroendocrine markers [neural cell adhesion molecule (NCAM), chromogranin A, and synaptophysin] by immunohistochemical methods in seven neuroendocrine tumors of the uterine cervix: five small cell carcinomas and two large cell neuroendocrine carcinomas. SSTR2A was expressed in one small cell carcinoma and two neuroendocrine large cell carcinomas. The cell membrane of cells in these carcinomas showed strong immunohistochemical reactivity for SSTR2A. SSTR2A-positive cases are also frequently positive for the expression of chromogranin A. Treatment with SSTR2A may be effective for endocrine tumors. The results indicate the usefulness of SSTR2A analogs for the treatment of some uterine neuroendocrine carcinomas.

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Citations

Feb 17, 2015·Case Reports in Urology·Toshikazu TanakaChikara Ohyama
Jul 10, 2012·Pathology, Research and Practice·Koji TsutaCesar A Moran
Apr 26, 2012·Rare Tumors·Benyam YosephArkadiusz Z Dudek
Jul 31, 2020·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Matthew Ryan CarrollMichael Frumovitz
May 8, 2018·BMC Cancer·Clemens B TempferGünther A Rezniczek
Mar 29, 2020·Cellular Oncology (Dordrecht)·B MahalakshmiBharath Kumar Velmurugan
Nov 17, 2020·Rare Tumors·Grant BurkeenSusanne Arnold
May 3, 2021·Critical Reviews in Oncology/hematology·Giuseppe CarusoInnocenza Palaia

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