PMID: 21566942Feb 1, 1994Paper

Immunohistochemical expression of the C-fos protein in preneoplastic and neoplastic lesions during hepatocarcinogenesis in rats

International Journal of Oncology
K AlexandreP Galand

Abstract

We performed an immunohistochemical study of the c-FOS protein, in the preneoplastic and neoplastic liver lesions in rats. The majority of the lesions at all stages contained an average of 50 to 60 percent of c-FOS immunopositive nuclei: This contrasted with the non-involved parenchyma, which exhibited a low incidence of positivity (less than 10 percent). No relation with proliferation or apoptosis was observed in the lesions, whereas the c-FOS protein was overexpressed within a few hours of partial hepatectomy. Moreover, our results indicate that increased c-FOS protein content is insufficient to elicit full malignancy.

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