Immunohistochemical expression of vascular endothelial growth factor correlates with positive surgical margins and recurrence in T1 and T2 squamous cell carcinoma (SCC) of the lower lip

Oral Oncology
P A KyzasN J Agnantis

Abstract

Tumor angiogenesis is associated with tumor progression and aggressiveness in a number of malignancies, and vascular endothelial growth factor (VEGF) is considered as a leading candidate in this process. The aim of the present study was to investigate the role of VEGF immunohistochemical expression and tumor angiogenesis in predicting local recurrence in surgically treated lip SCC. We performed a retrospective analysis of 50 patients with lip SCC in order to investigate whether VEGF immunohistochemical expression and tumor angiogenesis correlate with clinicopathologic parameters and outcome. Tumor angiogenesis was estimated by determining microvessel density (MVD) with the use of CD34 antibody. Our results showed that VEGF was strongly correlated with tumor invasion towards the surgical margin. There was also a significant association of high VEGF expression with a higher incidence of local recurrence (p < 0.001). We suggest that VEGF expression may be used as an index to distinguish patients with higher risk of relapse.

References

Jan 3, 1990·Journal of the National Cancer Institute·J Folkman
Jan 3, 1991·The New England Journal of Medicine·N WeidnerJ Folkman
Sep 20, 1990·The New England Journal of Medicine·W K HongL J Peters
Nov 1, 1995·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·R P ZitschJ L Rea
Jul 15, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·J G de VisscherI van der Waal
Jun 1, 2000·The Australian and New Zealand Journal of Surgery·D McCombeJ Matthews
Aug 5, 2000·International Journal of Radiation Oncology, Biology, Physics·D M AebersoldV Djonov
Jul 10, 2002·International Journal of Oral and Maxillofacial Surgery·J G A M de VisscherJ L N Roodenburg
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Jerome W BreslinWalter N Durán
Jan 23, 2003·Microscopy Research and Technique·Niels ReinmuthLee M Ellis
Aug 20, 2003·Archives of Otolaryngology--head & Neck Surgery·Rajesh V LallaDonald L Kreutzer

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Citations

Aug 6, 2009·Cancer Chemotherapy and Pharmacology·George FountzilasMarios Marselos
Apr 14, 2006·Virchows Archiv : an International Journal of Pathology·Panayiotis A KyzasDimitrios Stefanou
Jul 27, 2005·Journal of Cancer Research and Clinical Oncology·Panayiotis A KyzasNiki J Agnantis
Apr 9, 2010·Clinical and Experimental Medicine·Claudiu MărgăritescuDomenico Ribatti
Aug 4, 2009·Investigational New Drugs·Nicholas W ChoongEzra E W Cohen
Jul 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Panayiotis A KyzasNiki J Agnantis
Oct 12, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Panayiotis A KyzasNiki J Agnantis
Apr 3, 2012·Journal of Oral Science·Aguida Cristina G HenriquesRoseana de A Freitas
Apr 22, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Carla AriottiManoela Domingues Martins
Jun 2, 2012·International Journal of Oral and Maxillofacial Surgery·E Z MichailidouD Z Antoniades
Jan 1, 2008·Archives of Medical Research·Zeynep Nil UnalUğur Atik
Feb 20, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Xiaoan TaoBin Cheng
Nov 29, 2015·Brazilian Journal of Otorhinolaryngology·Mojgan Alaeddini, Shahroo Etemad-Moghadam
May 10, 2007·The British Journal of Dermatology·C UlrichC Termeer
Apr 24, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Fumi OhnoKenichi Kurita
Jun 28, 2005·Cancer Letters·Panayiotis A KyzasNiki J Agnantis
May 3, 2014·Seminars in Oncology·Joseph M CurryMadalina Tuluc
Dec 20, 2014·Pathology, Research and Practice·Haiwei WuDongsheng Zhang
Jun 7, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Helenisa Helena Oliveira-NetoAline Carvalho Batista
Sep 13, 2006·Journal of Surgical Oncology·Chih-Yen ChienChao-Cheng Huang
Nov 2, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Onder AkdenizBahar Müezzinoglu

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