Immunohistochemical features of cutaneous granulomas in primary immunodeficiency disorders: a comparison with cutaneous sarcoidosis

Journal of Cutaneous Pathology
Michelle de JagerMarieke Seyger

Abstract

Cutaneous granulomas can occur in patients with a primary immunodeficiency disorder. In some cases, an infectious cause cannot be revealed. The pathogenesis of these granulomas still remains to be elucidated. The aim of this study was to study differences or overlap between these rare granulomas and sarcoidosis-related granulomas. Markers for T-cell subsets (CD3, CD4, CD8 and CD45RO), Langerhans' cells (CD1a), macrophages (CD68), B cells (CD20) and NK cells (CD56) were stained immunohistochemically. The amount of CD4+ and CD8+ cells in the granulomas was counted. Results were compared with the CD4+/CD8+ ratio in peripheral blood. In the granulomas of two of three patients with a primary immunodeficiency disorder, the cytotoxic T cells (CD8+) outnumbered the T-helper cells (CD4+) with a counted CD4+/CD8+ ratio <1. In contrast, the granulomas in the cutaneous sarcoidosis patients showed a predominance of CD4+ cells, with CD4+/CD8+ ratios >2. A lower CD4+/CD8+ ratio was found in the cutaneous granulomas of patients with a primary immunodeficiency disorder (unclassified combined immunodeficiency, autoimmune lymphoproliferative syndrome and ataxia teleangiectasia) as compared with the patients with cutaneous sarcoidosis. The possibl...Continue Reading

References

Aug 1, 1979·The British Journal of Dermatology·K KeczkesD M Piercy
Nov 1, 1991·Journal of the American Academy of Dermatology·E C SiegfriedA S Paller
Dec 1, 1991·The Journal of Pediatrics·A S PallerM Swift
Apr 1, 1991·Journal of the American Academy of Dermatology·M G FlemingR W Pearson
Jun 1, 1995·Pediatric Dermatology·A TorreloA Zambrano
Jan 1, 1994·The British Journal of Dermatology·T S LevineA D Webster
Mar 1, 1997·The Journal of Pediatrics·W M Comans-BitterJ J van Dongen
May 8, 1999·The British Journal of Dermatology·P CornejoL Iglesias
Sep 19, 2003·Postgraduate Medical Journal·M TrevenzoliP Cadrobbi
Apr 30, 2004·Thorax·M OtaS Fukuhara
Apr 9, 2005·Revista iberoamericana de micología·Fátima Regina Vilani-MorenoDiltor Vladimir Araújo Opromolla
Jul 21, 2005·The British Journal of Dermatology·A MitraJ A Newton-Bishop
Jan 25, 2006·The Journal of Experimental Medicine·Makoto MiyaraGuy Gorochov

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Citations

Jul 9, 2010·Pediatric Dermatology·Curt A VogelJared J Lund
May 24, 2011·Clinical & Developmental Immunology·Matteo BordignonMauro Alaibac
Aug 31, 2011·Dermatology : International Journal for Clinical and Investigative Dermatology·L Y T ChiamM van Deuren
Feb 10, 2016·Current Allergy and Asthma Reports·Paul J Maglione
Jul 1, 2011·The Journal of Allergy and Clinical Immunology·Despina MoshousAlain Fischer
Jan 1, 2010·Journal of Cutaneous Pathology·Timothy H McCalmont
May 13, 2014·Journal of the American Academy of Dermatology·Bryan GammonJoan Guitart
Mar 17, 2015·International Journal of Dermatology·Joanna HarpTimothy G Berger
Nov 12, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Edith SchusslerPaul J Maglione
May 19, 2010·Expert Review of Clinical Immunology·E Graham Davies
Jan 6, 2016·Journal of Cutaneous Medicine and Surgery·Ilya ShoimerRichard M Haber
Oct 7, 2017·Current Allergy and Asthma Reports·Paul J MaglioneCharlotte Cunningham-Rundles
Mar 15, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·S Leclerc-MercierC Bodemer
Jul 26, 2014·The American Journal of Dermatopathology·Arti NandaHejab Al-Ajmi
Nov 1, 2011·Pediatric Transplantation·Daan Van BrusselenRita Van Damme-Lombaerts
Oct 13, 2020·Current Opinion in Allergy and Clinical Immunology·Ludmila PerelyginaKathleen E Sullivan
Nov 20, 2021·The American Journal of Dermatopathology·Connor J StonesiferLarisa J Geskin

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