Abstract
Verrucous carcinoma (VC) is a rare subtype of squamous cell carcinoma, with the majority of cases occurring in the oral cavity and genital area. The present study describes a rare case of cutaneous VC of the neck manifesting as a semi-pedunculated multinodular protrusion. Histological analysis revealed thickening of the epidermis and papillary growth. Although cellular atypia was generally mild, a large number of mitoses were observed, of which a small number were abnormal. Additionally, bulbous subepidermal invasion was observed. The lesion was differentiated from papillary squamous cell carcinoma, another rare subtype of squamous cell carcinoma, based on the presence of epidermal verrucous growth and the lack of remarkable nuclear atypia. Benign disorders, including seborrheic keratosis, fibroepithelial polyp, verruca vulgaris and pseudocarcinomatous hyperplasia, were also differentiated from the lesion. Immunohistochemical analysis of cytokeratin (CK)10 expression revealed attenuated staining of the lesion, therefore, anti-CK10 immunohistochemistry may be valuable in the diagnosis of VC.
References
Apr 1, 1990·Journal of Cutaneous Pathology·G LandmanK J Friedman
Jan 1, 1995·Journal of the American Academy of Dermatology·R A Schwartz
Jun 10, 2000·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·G Petter, U F Haustein
Aug 3, 2001·Cancer Control : Journal of the Moffitt Cancer Center·M H RinkerL F Glass
Mar 21, 2003·Virchows Archiv : an International Journal of Pathology·Daniel AzorínJavier Salamanca
Dec 24, 2003·Journal of Cutaneous Pathology·Chalid AssafConstantin E Orfanos
Aug 12, 2006·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Giorgio De TomaNicolò Scuderi
Jul 11, 2009·The American Journal of Dermatopathology·Meghan Dubina, Gary Goldenberg
May 27, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Mia E MillerAkira Ishiyama
Jul 28, 2010·Biochemical and Biophysical Research Communications·Yoshito YamashiroKen-ichi Kariya
Oct 14, 2011·The American Journal of Dermatopathology·Jinane El-KhouryOssama Abbas
Jan 13, 2012·Journal of Cutaneous Pathology·Almut Böer-AuerOlesya V Lyasnichaya
Sep 18, 2013·World Journal of Surgical Oncology·Marileda IndinnimeoVincenzo Tombolini