PMID: 8601696Apr 1, 1996Paper

Immunohistochemical heterogeneity of nerve cells in the human adrenal gland with special reference to substance P

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
M Colombo-BenkmannC Heym

Abstract

Neurons in the human adrenal medulla, stained by the NADH-diaphorase reaction, were counted and their neurochemical markers were investigated by double labeling immunofluorescence with special reference to substance P. The findings indicate a significant participation of intramedullary nerve cell bodies in human adrenal innervation with 40.4 neurons/mm3 adrenal medulla. Substance P-immunoreactive neurons, which made up approximately 20% of all neurons, exhibited heterogeneity by co-localization of immunoreactivities for dynorphin, for cholecystokinin, and for neurofilament triplet. Substance-P-immunolabeled neurons were always nonreactive for calcitonin gene-related peptide, for vasoactive intestinal polypeptide, or for tyrosine hydroxylase, the rate-limiting enzyme of catecholamine synthesis. These chemical phenotypes of intramedullary neurons reveal immunohistochemical similarities with postganglionic neurons in parasympathetic ganglia or with enteric neurons, suggesting a hitherto unrecognized functional significance of the intrinsic nervous system in the human adrenal gland.

Citations

Jul 15, 1998·Peptides·G G Nussdorfer, L K Malendowicz
Sep 23, 2014·Acta histochemica·Mohamed A Elnasharty, Ahmed Sayed-Ahmed
Jul 4, 2021·Molecular and Cellular Endocrinology·Antoine-Guy LopezEstelle Louiset

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