Abstract
The aim of the present study was to investigate the presence and the distribution of cells containing orexin A and orexin type 2 receptor in the horse stomach and gut, by means of immunohistochemical techniques. Orexin A was identified in the stomach fundic and pyloric regions and in the duodenum. In the same stomach regions, a large subset of orexin A-positive cells also showed orexin type 2 receptor-like immunoreactivity. Moreover, in the duodenum, many of them, seemed to store serotonin. Characteristically, enteric neurons or ganglia also displayed orexin A and, sometimes, orexin type 2 receptor immunoreaction. Orexin A and orexin type 2 receptor immunoreactivity was also found in the nerve fibers in the enteric submucosal layer. Our results, together with data present in the literature, could contribute to the understanding of complex mechanisms regulating the horse gut functionality that are depending very likely on the consequence of the co-operation of both a central and a peripheral control.
References
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·L L Bernardis, L L Bellinger
Mar 10, 1998·Cell·T SakuraiM Yanagisawa
Mar 17, 1999·The Journal of Endocrinology·C M EdwardsS R Bloom
Dec 10, 1999·Regulatory Peptides·T Sakurai
Jan 7, 2000·Neuron·A L Kirchgessner, M Liu
May 29, 2001·European Journal of Endocrinology·G KomakiC Kubo
Dec 19, 2001·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·María J Sánchez de Miguel, María A Burrell
Feb 14, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·E NäslundA L Kirchgessner
Feb 15, 2002·Endocrine Reviews·Annette L Kirchgessner
Aug 23, 2002·Pharmacology & Therapeutics·Darren Smart, Jeffrey Jerman
Nov 7, 2002·American Journal of Physiology. Cell Physiology·Jyrki P KukkonenKarl E O Akerman
Aug 2, 2003·Molecular and Cellular Endocrinology·Masao NakabayashiHironobu Sasano
Aug 18, 2004·The Journal of Biological Chemistry·Patricia Rouet-BenzinebThierry Voisin
Jan 27, 2005·The Journal of Clinical Endocrinology and Metabolism·M EhrströmE Näslund
Mar 31, 2005·The Journal of Clinical Endocrinology and Metabolism·R SpinazziG G Nussdorfer
Jun 22, 2007·Physiology & Behavior·Erik Näslund, Per M Hellström
Jul 14, 2007·Diabetes·Robert DucrocMarc Laburthe
Dec 7, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Elena ValassiFrancesco Cavagnini
Jan 15, 2008·Regulatory Peptides·Christian R BaumannThomas E Scammell
Jan 24, 2008·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Finizia RussoAlfredo Vittoria
Feb 26, 2008·Acta Physiologica·M V HeinonenK H Herzig
Citations
Apr 22, 2014·Acta histochemica·Cecilia Dall'AglioPiero Ceccarelli
Mar 15, 2013·Research in Veterinary Science·C Dall'aglioC Boiti
May 10, 2011·Research in Veterinary Science·C Dall'AglioC Boiti
Apr 3, 2010·Research in Veterinary Science·C Dall'AglioP Ceccarelli
Nov 13, 2015·General and Comparative Endocrinology·Deepanshu Joshi, Shio Kumar Singh
Jun 12, 2013·Acta histochemica·Finizia RussoEttore Varricchio
Sep 6, 2011·Regulatory Peptides·Cecilia Dall'AglioCristiano Boiti
Apr 3, 2012·Peptides·Cecilia Dall'aglioCristiano Boiti
Mar 15, 2011·Acta histochemica·Cecilia Dall'AglioPiero Ceccarelli
Aug 22, 2014·PloS One·Claudia GattaLucianna Maruccio
Jul 5, 2012·Pharmacological Reviews·Anthony L GotterChristopher J Winrow
Jul 6, 2021·Metabolic Brain Disease·Idris A AzeezJames O Olopade