Immunohistochemical identification and localization of orexin A and orexin type 2 receptor in the horse gastrointestinal tract

Research in Veterinary Science
C Dall'AglioP Ceccarelli

Abstract

The aim of the present study was to investigate the presence and the distribution of cells containing orexin A and orexin type 2 receptor in the horse stomach and gut, by means of immunohistochemical techniques. Orexin A was identified in the stomach fundic and pyloric regions and in the duodenum. In the same stomach regions, a large subset of orexin A-positive cells also showed orexin type 2 receptor-like immunoreactivity. Moreover, in the duodenum, many of them, seemed to store serotonin. Characteristically, enteric neurons or ganglia also displayed orexin A and, sometimes, orexin type 2 receptor immunoreaction. Orexin A and orexin type 2 receptor immunoreactivity was also found in the nerve fibers in the enteric submucosal layer. Our results, together with data present in the literature, could contribute to the understanding of complex mechanisms regulating the horse gut functionality that are depending very likely on the consequence of the co-operation of both a central and a peripheral control.

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Citations

Mar 15, 2013·Research in Veterinary Science·C Dall'aglioC Boiti
May 10, 2011·Research in Veterinary Science·C Dall'AglioC Boiti
Apr 3, 2010·Research in Veterinary Science·C Dall'AglioP Ceccarelli
Nov 13, 2015·General and Comparative Endocrinology·Deepanshu Joshi, Shio Kumar Singh
Jun 12, 2013·Acta histochemica·Finizia RussoEttore Varricchio
Apr 3, 2012·Peptides·Cecilia Dall'aglioCristiano Boiti
Mar 15, 2011·Acta histochemica·Cecilia Dall'AglioPiero Ceccarelli
Jul 6, 2021·Metabolic Brain Disease·Idris A AzeezJames O Olopade

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