PMID: 8971816Nov 29, 1996Paper

Immunohistochemical investigation of human leukocyte antigen (HLA)-DR-positive astrocytes in adrenoleukodystrophy brain

Neuroscience Letters
T KatsuragiM Kato

Abstract

We investigated immunohistochemically the expression of human leukocyte antigen (HLA)-DR in postmortem brain tissue of two adult patients with adrenoleukodystrophy (ALD). In addition to microglia and macrophages, a significant number of star-like cells were stained positively for HLA-DR in demyelinating lesions of both patients. Such cells congregated in the peripheral zone of the lesions. A mirror image analysis as well as double immunostaining for HLA-DR and glial fibrillary acidic protein established that these cells were a subset of reactive astrocytes. Together with other reports demonstrating that astrocytes express HLA-DR only under very limited conditions, the results of this study suggest the involvement of immune and inflammatory responses in the pathological processes of ALD.

References

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Citations

Jul 27, 2007·Acta Neuropathologica·Kyoko SuzukiYoshio Hirayasu
Jan 27, 2021·The Journal of Comparative Neurology·Karthik RaviArumugam R Jayakumar

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