Immunohistochemical investigation of SV40 large T antigen in Hodgkin and non-Hodgkin's lymphoma

International Journal of Cancer. Journal International Du Cancer
Pierre BroussetRandy D Gascoyne

Abstract

DNA sequences from simian virus 40 (SV40) have been detected in various human tumors, including non-Hodgkin's lymphomas (NHLs), by highly sensitive PCR techniques. However, there is a strong debate as to whether SV40 is present in lymphoma cells. Using immunohistochemistry and tissue microarrays, we investigated a series of French and Canadian cases of Hodgkin's lymphomas (HLs) and NHLs and tried to detect the SV40 large T antigen using routine paraffin sections with standard and highly sensitive catalyzed system amplification methods. None of the cases of HLs (n = 250) or NHLs (n = 232) were found to contain a single large T antigen-positive cell, whereas 2 positive controls were repeatedly stained. Therefore, our results do not support the hypothesis that SV40 is implicated in the etiology of human lymphomas.

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Citations

Aug 9, 2006·Current Opinion in Oncology·Susan G Fisher, Richard I Fisher
Mar 26, 2005·Journal of Clinical Pathology·J SabatierP Brousset
Aug 23, 2006·Leukemia & Lymphoma·Katherine S WilsonRuth F Jarrett
Apr 29, 2006·Acta Oncologica·Karin Ekström-Smedby
Jul 28, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Sonia ToracchioJanet S Butel
Oct 11, 2005·Hematological Oncology·Daniela CapelloGianluca Gaidano
Nov 30, 2006·International Journal of Cancer. Journal International Du Cancer·Keerti V Shah
Apr 23, 2008·Journal of Medical Virology·Philip WentStephan Dirnhofer
Jul 30, 2005·International Journal of Cancer. Journal International Du Cancer·Frank SchülerGottfried Dölken
Dec 20, 2005·The Journal of Pathology·Ruth F Jarrett
Sep 10, 2015·Cellular Oncology (Dordrecht)·Myriam Ben DhiabMounir Trimeche
Nov 26, 2015·Analytical Cellular Pathology (Amsterdam)·Rehab M SamakaNanes S Holah
Sep 12, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danielle L Poulin, James A DeCaprio
Mar 4, 2020·FASEB BioAdvances·Xiyong FanAnthony M George

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