Immunohistochemical localization of alpha(1a)-adrenoreceptors in muscle spindles of rabbit masseter muscle

Tissue & Cell
C BombardiM L Lucchi

Abstract

The expression of alpha(1a)-adrenoreceptors (alpha(1a)-ARs) within the muscle spindles of rabbit masseter muscle was investigated. The alpha(1a)-ARs were detected by immunohistochemical fluorescent method and examined along the entire length of 109 cross serially sectioned spindles. The sympathetic fibers were visualized by the immunofluorescent labeling of the noradrenaline synthesizing enzymes tyrosine hydroxylase (TH) and dopamine beta-hydroxylase (DBH). In order to recognize the intrafusal muscle fiber types, antibodies for different myosin heavy chain isoforms (MyHCI) were used. TH and DBH immunolabeled nerve fibers have been observed within the capsule lamellar layers, in the periaxial fluid space and close to intrafusal muscle fibers. The alpha(1a)-ARs were detected on the smooth muscle cells of the blood vessels coursing in the muscle and in the capsule lamellar layers or within the periaxial fluid space of the spindles. Moreover, at the polar regions of a high percentage (88.1%) of muscle spindles a strong alpha(1a)-ARs immunoreactivity was present on the intrafusal muscle fibers. In double immunostained sections for alpha(1a)-ARs and MyHCI it was evidenced that both bag, and nuclear chain fibers express alpha(1a)-ARs....Continue Reading

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Citations

Oct 13, 2006·European Journal of Applied Physiology·Magda Passatore, Silvestro Roatta
Jun 29, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·H OgataK Nakazawa
Apr 20, 2010·Autonomic Neuroscience : Basic & Clinical·Hiroshi YasuiHisao Nishijo
Mar 26, 2014·Journal of Anatomy·Kevin PeikertChristian Albrecht May
Jan 16, 2007·Archives of Oral Biology·Magda Passatore, Silvestro Roatta
Nov 5, 2014·Muscle & Nerve·Kevin Peikert, Christian Albrecht May
May 23, 2015·Journal of Anatomy·Dina RadovanovicFatima Pedrosa Domellöf
Nov 4, 2017·Journal of Anatomy·Astrid MayChristian Albrecht May
Dec 17, 2008·The British Journal of Social Psychology·Fiona Kate BarlowMiles Hewstone
Sep 3, 2011·The British Journal of Social Psychology·Jonathan E CookBertram F Malle
Sep 3, 2011·The British Journal of Social Psychology·Miles Hewstone, Hermann Swart

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