PMID: 9539203Apr 16, 1998Paper

Immunohistochemical localization of angiotensin II in the mouse pancreas

The Histochemical Journal
P S LeungP Y Wong

Abstract

Previous studies have suggested the presence of a tissue renin-angiotensin II system in the pancreas. These studies were based on the observation of several key components of the renin-angiotensin II system using molecular biological, biochemical and pharmacological approaches. In the present study, angiotensin II was localized immunohistochemically in the mouse pancreas using an indirect immunoperoxidase-staining technique. The results showed that angiotensin II-like immunoreactivity was localized predominantly in the endothelial cells of pancreatic blood vessels and the epithelial cells of pancreatic ducts from a subgroup of the vessels and ducts. Compared with those found in the pancreatic blood vessels and ductal system, a less pronounced immunoreactivity for angiotensin II was also observed in the acinar cells and in the smooth muscle layers overlying the pancreatic ducts as well as the blood vessels. However, no angiotensin II-like immunoreactivity was detected in the islet cells. Taken together with previous findings, the present results suggest a local angiotensin II-forming system in the mouse pancreas, which may be a significant autocrine or paracrine modulator of diverse pancreatic functions, including regulation of ...Continue Reading

Citations

Jan 10, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Kelly PutnamLisa A Cassis
Mar 19, 2004·Pancreas·Roland ReinehrDieter Häussinger
Nov 4, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Harshita ChodavarapuEric Lazartigues
Jan 16, 2007·The Journal of Physiology·Po Sing Leung
Jul 31, 2013·IUBMB Life·Kavaljit H ChhabraEric Lazartigues
Mar 7, 2013·American Journal of Physiology. Endocrinology and Metabolism·Kavaljit H ChhabraEric Lazartigues
Feb 17, 2006·The Prostate·Hiroji UemuraYoshinobu Kubota
Jan 20, 2018·Physiological Reviews·Robson Augusto Souza SantosMaria Jose Campagnole-Santos
Jul 4, 2006·Physiological Reviews·Martin PaulReinhold Kreutz
Feb 22, 2002·The Journal of Surgical Research·Marissa Howard-McNatt, Aaron S Fink
Jul 18, 2002·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·S P IpP S Leung
Oct 4, 2005·The International Journal of Biochemistry & Cell Biology·C TikellisM C Thomas
Feb 23, 2010·Regulatory Peptides·Felicia M RabeyRobert C Speth

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