Immunohistochemical localization of CA130 in fetal tissues, and in normal and neoplastic tissues of the female genital tract

Asia-Oceania Journal of Obstetrics and Gynaecology
Y NanbuK Endo

Abstract

A murine monoclonal antibody, 130-22, produced against a human lung adenocarcinoma cell line (PC-9) has been suggested as recognizing an antigenic determinant (CA130) which is different from an epitope recognized by OC125 on CA125 glycoprotein molecules. The immunohistochemical reactivity with the 130-22 antibody (anti-CA130) was examined in human fetal tissues, and normal and neoplastic tissues of female genital tracts, and compared to those using OC125. Among the fetal tissues, the amnion and the cells of coelomic epithelium and mullerian-derived epithelia reacted with anti-CA130. In normal adult tissues, cervical and endometrial gland cells, tubal epithelial cells, and ovarian surface cells reacted with anti-CA130. In addition, predecidual cells in the late secretory endometrium and decidual cells during gestation were positive. Among the neoplastic tissues, tubal and endometrial adenocarcinomas and epithelial ovarian tumors were positive for anti-CA130. There were no differences in the respective specimens between the immunohistochemical localization of anti-CA130 and of OC125. Therefore, anti-CA130 is considered to be useful in the immunohistochemical detection of CA125 glycoprotein molecules as well as OC125.

References

May 1, 1986·American Journal of Obstetrics and Gynecology·H W de BruijnG J Fleuren
Jun 1, 1986·Fertility and Sterility·P E PattonC B Coulam
Aug 1, 1989·American Journal of Obstetrics and Gynecology·Y NanbuT Mori
Jul 1, 1986·American Journal of Obstetrics and Gynecology·T J O'BrienJ G Quirk
Jan 1, 1983·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·S E KabawatR B Colvin
Apr 15, 1984·American Journal of Obstetrics and Gynecology·J M NiloffR C Bast
Oct 13, 1983·The New England Journal of Medicine·R C BastR C Knapp
Nov 1, 1981·The Journal of Clinical Investigation·R C BastR C Knapp

❮ Previous
Next ❯

Citations

Nov 17, 2017·Archives of Gynecology and Obstetrics·Xaveer Van OstadeGeert Van Raemdonck

❮ Previous
Next ❯

Related Concepts

Related Feeds