PMID: 7030456Dec 21, 1981Paper

Immunohistochemical localization of catechol-O-methyltransferase in circumventricular organs of the rat: potential variations in the blood-brain barrier to native catechols

Brain Research
G P KaplanC R Creveling

Abstract

Catechol-O-methyltransferase (COMT) was localized in the organum vasculosum of the lamina terminals, subfornical organ, subcommissural organ and area postrema of rat brain using an indirect immunofluorescence technique. COMT immunofluorescence was apparent in neuroglia within the organum vasculosum and was most intense in the ependyma between this structure and the optic recess of the third ventricle. In both the subfornical organ and the area postrema, COMT was localized in a neuroglial network, but was noticeably absent in the ependymal layer. COMT immunofluorescence in the ependyma of the subcommissural organ was continuous with the more intense immunofluorescence of the cuboidal ependyma of the third ventricle. Each of the circumventricular organs studied, with the exception of the subcommissural organ, lies outside the blood-brain barrier. However, the unique pattern of COMT immunofluorescence in the area postrema and the subfornical organ suggests that these two structures, of all circumventricular organs, are most likely to permit the entry of peripherally circulating catechols to the cerebrospinal fluid.

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Citations

Jan 1, 1982·Pharmacology & Therapeutics·N Bodor, M E Brewster
Aug 16, 1995·Biochimica Et Biophysica Acta·K LundströmI Ulmanen
Jan 1, 1986·Neurochemistry International·W E HeydornD M Jacobowitz
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Jul 1, 1996·Neuroscience·T KarhunenP Panula
Dec 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T KarhunenP Panula
Oct 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·P LevittX O Breakefield
Sep 29, 2011·The Journal of Comparative Neurology·Tony J SapsfordDavid R Grattan
Oct 23, 2002·Archives of Histology and Cytology·Koichi Ogawa
May 8, 2013·The Journal of Comparative Neurology·Fanny LangletBenedicte Dehouck
Sep 30, 2014·The Journal of Comparative Neurology·Rajamani SelvamWayne J Kuenzel
Jan 30, 2018·Frontiers in Neuroanatomy·Marta García-LeceaVladimir Korzh
Oct 12, 2004·Experimental Neurology·Hazel C JonesBarbara J Carter
Feb 15, 1989·Biochemical and Biophysical Research Communications·M H GrossmanX O Breakefield

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