PMID: 7545884Jun 1, 1995Paper

Immunohistochemical localization of connexin 43 in the developing tooth germ of rat

Anatomy and Embryology
M KagayamaY Sasano

Abstract

Distribution of gap junction protein in maxillary tooth germs of 1-day-old rats was examined by immunohistochemistry, using an affinity-purified antibody specific to residues 360-376 of rat connexin (CX) 43. In 1-day-old rats, the maxillary second molar formed the shape of the cusp, but neither dentine nor enamel was formed between the cells of the dental papilla and the inner enamel epithelium. In the tooth germ, CX 43 was expressed in the cells of the stratum intermedium and the inner enamel epithelium. Labelling in the stratum intermedium was extensive and showed an increasing gradient from peripheral to cuspal regions. CX 43 detected in the inner enamel epithelium was at cell surfaces facing the interface between the dental papilla and the inner enamel epithelium. The cells of the dental papilla and the inner enamel epithelium began differentiation as odontoblasts and secretory ameloblasts respectively, in the cusps of the first molars, where predentine and dentine were formed but enamel matrix was not secreted. CX 43 was present in the stratum intermedium, inner enamel epithelium, preodontoblasts, odontoblasts and subodontoblasts. The incisors showed the most advanced stage of development, where the enamel matrix and calci...Continue Reading

Citations

Oct 24, 2008·Journal of Dental Research·A FenwickM J Dixon
Aug 8, 2013·Microscopy Research and Technique·Takashi MuramatsuMasaki Shimono
Nov 12, 2016·Journal of Dental Research·M Ishikawa, Y Yamada
Jul 13, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Trevor J PembertonPragna I Patel
Dec 20, 2002·Connective Tissue Research·Imad AboutJean-Claude Franquin
Jan 28, 2003·Histochemistry and Cell Biology·Silvia M A João, Victor E Arana-Chavez

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