Immunohistochemical localization of cytokeratins and involucrin in calcifying epithelioma: comparative studies with normal skin

The British Journal of Dermatology
S WatanabeH Takahashi

Abstract

The expression of cytokeratins and involucrin varies greatly in different epithelia, and this raises the possibility that detailed analysis of these epidermal proteins might provide a means of identifying various skin tumours. The present study was conducted to determine the immunohistochemical distribution of cytokeratins and involucrin in calcifying epithelioma of Malherbe, in order to elucidate the nature and differentiation of this tumour. To correlate the immunohistochemical profile with the most frequent histological patterns, we categorized the basophilic, transitional, shadow, and squamoid cells, and the shreds of keratin. Comparative studies with normal skin showed that the shadow and transitional cells corresponded to hair cortex cells, the squamoid cells to the outer root sheath, the basophilic cells adjacent to the stroma to the outermost cell layer of the outer root sheath between the lower permanent portion and upper transient portion of the follicles, and the basophilic cells adjacent to the transitional cells to the hair matrix. The expression of cytokeratins in most shreds of keratin was similar to that in squamoid cells. Calcifying epithelioma was, therefore, shown to be composed of tumour cells differentiatin...Continue Reading

References

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Citations

Aug 1, 1995·The British Journal of Dermatology·T Ohnishi, S Watanabe
Aug 14, 1999·The American Journal of Dermatopathology·T Ohnishi, S Watanabe
Aug 21, 2003·The Journal of Dermatology·Takahito MorikawaShinichi Watanabe
Sep 21, 2006·Experimental Dermatology·Daniela KovacsMauro Picardo
Nov 24, 2006·The American Journal of Dermatopathology·Wataru Nishie, Tetsunori Kimura
Jun 1, 1996·The American Journal of Dermatopathology·S WatanabeS Harada
May 11, 1999·Journal of Cutaneous Pathology·T Nakamura
Nov 9, 2000·The British Journal of Dermatology·I KurokawaA Tsubura
May 22, 2001·The British Journal of Dermatology·B CribierE Grosshans
Feb 11, 2005·Journal of Cutaneous Pathology·Hideki MienoShingo Tajima
Nov 23, 2012·Clinical and Experimental Dermatology·T Tempark, T Shwayder
Oct 23, 1997·The American Journal of Dermatopathology·T Ohnishi, S Watanabe
Oct 18, 2002·Histopathology·L RiccioniG Collina
Jan 26, 2018·Journal of Cutaneous Pathology·Katherine Tumminello, Gregory A Hosler
Jul 2, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·Leonardo BugattiCarlo Tomasini
May 14, 2004·The Journal of Investigative Dermatology·Bernard CribierJürgen Schweizer

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