Immunohistochemical localization of factor X-like antigen in pancreatic islets and their tumours

Virchows Archiv. A, Pathological Anatomy and Histopathology
C BordiC Betterle


The authors have investigated by immunohistochemistry the distribution of factor X-like antigen in normal pancreatic islets and in a series of 46 pancreatic endocrine tumours. It was found that both glucagon-producing (A) cells and pancreatic polypeptide-producing (PP) cells are immunoreactive for the antigen. Benign glucagonomas and PP-omas presented the highest concentrations of immunoreactive material whose intracellular distribution was consistent with localization within cell secretory granules. Some benign insulinomas also presented factor X immunostaining in spite of the absence of the antigen in normal insulin-producing B cells. Although malignant tumours usually exhibited very low or no immunostaining, two of three malignant glucagonomas showed scattered, intensely immunoreactive cells. The factor X-like antigen identified in this study was found to differ from chromogranin A and B. The possible implications of the present findings for coagulative disorders associated with glucagonomas or diabetes are discussed.


Jan 1, 1988·Virchows Archiv. A, Pathological Anatomy and Histopathology·C BordiT D'Adda
Aug 1, 1987·American Journal of Clinical Pathology·C BordiA Peracchia
May 30, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·A GirolamiM A Vicarioto
Mar 11, 1982·The New England Journal of Medicine·S R Friesen
Jan 1, 1984·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·G BussolatiA Sapino
Dec 1, 1982·Blut·C BetterleA Girolami

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