PMID: 2096111Dec 1, 1990Paper

Immunohistochemical localization of inhibin-alpha in the testes of normal men and in men with testicular disorders

International Journal of Andrology
A Bergh, S Cajander

Abstract

Testicular biopsies from normal men and from men with testicular disorders were examined by immunohistochemistry for the presence of the inhibin-alpha subunit using two different antisera. Immunoreactive inhibin-alpha (irI-alpha) was found in Leydig cells in normal, oligospermic, and azoospermic men and in men with Klinefelter's syndrome, and it was also found in a Leydig cell tumour. hCG-treatment apparently increased the amount of immunoreactive inhibin-alpha, particularly in Leydig cells. Sertoli cells also contained irI-alpha but the staining intensity was considerably stronger in testes with impaired spermatogenesis or Sertoli-cell-only syndrome than in normal testes. It is suggested that the serum concentration of irI-alpha and inhibin in humans may, in a complex way, be related to both Leydig and Sertoli cell function, and that the relative contribution from these cells may change in cases of testicular malfunction.

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Citations

Aug 1, 1993·Cell and Tissue Research·M K VliegenE Nieschlag
Mar 1, 1993·Cell and Tissue Research·M S DavidoffA F Holstein
Oct 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·G FortiM Serio
Apr 15, 2004·European Urology·A M WinstanleyUNKNOWN Eurpean Association of Pathologists, Uropathology Division in Florence
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Jun 9, 2000·International Journal of Andrology·R A Anderson, R M Sharpe
Apr 12, 2001·International Journal of Andrology·D Kinniburgh, R A Anderson
Dec 3, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Gian Franco ZannoniGiovanni Neri
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May 1, 1992·Archives of Andrology·S B MoodbidriA R Sheth

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