PMID: 7939173Jan 1, 1994Paper

Immunohistochemical localization of insulin-like growth factor 1 receptors in benign and malignant tissues of the female genital tract

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
B WeigangW Jaeger

Abstract

The distribution of insulin-like growth factor I (IGF-1) receptors in the female genital tract was examined by immunohistochemistry. The monoclonal antibody alpha-IR-3, which binds to the alpha-subunits of the IGF-1 receptor, was used for specific binding and the peroxidase-antiperoxidase method was used for staining. IGF-1 receptors were consistently detected in the epithelium of cervix, endometrium and the fallopian tube. Furthermore, high expression of the IGF-1 receptors was found in ovarian cancer tissue, where predominantly the stromal cells around the vessels gave an intense staining. Since the expression of the IGF-1 receptors in tumor epithelium was only weak and inconsistent, it is tempting to speculate that the stromal compartment in ovarian cancer is the target tissue for the effects of IGF-1.

Citations

Mar 27, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·D KatsarosM Massobrio
Jan 14, 2010·Journal of Oncology·Marie-Claude BeauchampWalter H Gotlieb
Jan 9, 2013·Expert Opinion on Therapeutic Targets·Ilan Bruchim, Haim Werner
May 27, 2014·Frontiers in Oncology·Ben DavidsonReuven Reich
Jul 16, 2014·Oncotarget·Zaid Al-WahabRamandeep Rattan
Jan 26, 2008·Zoological Science·Sanath Rajapakse, Takayuki Takahashi

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