PMID: 8583626Mar 1, 1996Paper

Immunohistochemical localization of insulin-like growth factor binding proteins 2 and 3 in prostate tissue: clinical correlations

The Journal of Urology
J B ThrasherS R Plymate

Abstract

The insulin-like growth factor system has recently been shown to have important mitogenic effects in the prostate. The system consists of 2 ligands: insulin-like growth factor types 1 and 2, which are potent mitogens for prostate cell growth, and 6 insulin-like growth factor binding proteins that modify the activity of these growth factors. Recently, changes in serum levels of insulin-like growth factor binding proteins 2 and 3 have been identified in prostate cancer patients but in vivo studies of these changes have not been previously reported. We performed immunohistochemical staining for insulin-like growth factor binding proteins 2 and 3 in areas of benign disease, prostatic intraepithelial neoplasia, and cancer from specimens obtained from 24 patients who underwent prostatectomy to determine changes in the quantity of these proteins with progression from the benign through the premalignant and into the malignant states. Quantification of the differences noted in the amount of insulin-like growth factor binding proteins 2 and 3 found in each of the 3 tissue types was then correlated with serum and tissue prostate specific antigen levels, pathological stage and grade of the tumors. Our data indicate that as human prostate t...Continue Reading

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Citations

Jan 7, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Alixanna M NorrisKarin D Scarpinato
May 9, 2003·The Urologic Clinics of North America·Eduardo I CantoKevin M Slawin
Mar 17, 2015·Frontiers in Endocrinology·Adam Pickard, Dennis J McCance
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shahrokh F ShariatKevin M Slawin
Feb 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Lívia L CorrêaMônica R Gadelha
Nov 13, 2002·European Journal of Clinical Nutrition·L S AugustinC La Vecchia
Apr 25, 2007·British Journal of Cancer·A S PerryM Lawler

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