PMID: 8600780Apr 1, 1995Paper

Immunohistochemical localization of keratins and involucrin in solar keratosis and Bowen's disease

The American Journal of Dermatopathology
E IchikawaF Otsuka

Abstract

The present study was conducted to determine the patterns of immunohistochemical characterization of keratin (K) and involucrin in solar keratosis and Bowen's disease in order to clarify the abnormal differentiation or maturation of the tumor cells in these precancerous epithelial dermatoses. Seventeen human anti-cytokeratin antibodies and an anti-involucrin antibody were used to examine 15 cases of solar keratosis and 18 cases of Bowen's disease. Formalin-fixed and paraffin-embedded sections were stained with these antibodies by the avidin-biotin-peroxidase technique. In solar keratosis, keratin and involucrin distribution was similar to that in normal epidermis, whereas in Bowen's disease the keratin distribution varied among individual cases. The dyskeratotic cells in Bowen's disease showed a reduction or loss of staining with these antibodies, and they were occasionally positive for keratin 19. These observations suggest that there is a difference in keratin and involucrin expression between solar keratosis and Bowen's disease and that the atypical cells of Bowen's disease exhibit a diversity of differentiation.

Citations

Mar 4, 2017·The Journal of Dermatology·Shin-Ichi Ansai
Feb 14, 2004·The Australasian Journal of Dermatology·John P Arlette, Martin J Trotter
May 10, 2018·The American Journal of Dermatopathology·Takeshi NamikiShin-Ichi Ansai
Aug 22, 2006·Journal of Cutaneous Pathology·Figen AslanNükhet Tüzüner
Jul 21, 2007·Journal of Cutaneous Pathology·Patricia R CuryVera C de Araújo
Aug 14, 1999·The American Journal of Dermatopathology·T Ohnishi, S Watanabe
Apr 12, 2003·Journal of Cutaneous Pathology·Jean N dos SantosVera C de Araújo
Jun 1, 1996·The American Journal of Dermatopathology·S WatanabeS Harada
Jun 22, 2013·International Journal of Dermatology·Nobuko YoshimiIchiro Kurokawa

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